Journal of Medicinal Chemistry p. 6651 - 6665 (2013)
Update date:2022-08-15
Topics: Structure-activity relationships (SAR) Therapeutic applications Phosphodiesterase Inhibition Safety and Toxicity
Cui, J. Jean
Shen, Hong
Tran-Dubé, Michelle
Nambu, Mitchell
McTigue, Michele
Grodsky, Neil
Ryan, Kevin
Yamazaki, Shinji
Aguirre, Shirley
Parker, Max
Li, Qiuhua
Zou, Helen
Christensen, James
The hepatocyte growth factor (HGF)/c-Met signaling axis is deregulated in many cancers and plays important roles in tumor invasive growth and metastasis. An exclusively selective c-Met inhibitor (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)- [1,2,4]triazolo[4,3-
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Doi:10.1021/jm7010518
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