Synthesis and Opioid Activity of Dermorphin Tetrapeptides Bearing D-Methionine S-Oxide at Position 2

Article abstract of DOI:10.1021/jm00156a003

Eight new dermorphin tetrapeptides, X-Tyr-D-MetO-Phe-aa-Y (X = H, H2N=C(NH); aa = Gly, 2-aminoethanol, sarcosine; Y = NH2, NH-alkyl), were prepared and tested for opioid activity.They show dose-related naloxone-reversible opioid effects in vitro and in vi