Bioorganic and Medicinal Chemistry Letters p. 159 - 163 (2008)
Update date:2022-07-29
Topics:
Yao, Wenqing
Zhuo, Jincong
Burns, David M.
Li, Yun-Long
Qian, Ding-Quan
Zhang, Colin
He, Chunhong
Xu, Meizhong
Shi, Eric
Li, Yanlong
Marando, Cindy A.
Covington, Maryanne B.
Yang, Gengjie
Liu, Xiangdong
Pan, Max
Fridman, Jordan S.
Scherle, Peggy
Wasserman, Zelda R.
Hollis, Gregory
Vaddi, Kris
Yeleswaram, Swamy
Newton, Robert
Friedman, Steve
Metcalf, Brian
In an effort to obtain a MMP selective and potent inhibitor of HER-2 sheddase (ADAM-10), the P1′ group of a novel class of (6S,7S)-7-[(hydroxyamino)carbonyl]-6-carboxamide-5-azaspiro[2.5]octane-5-carboxylates was attenuated and the structure-activity rela
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