The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies

DOI: 10.1021/jm701303z

Source and publish data:

Journal of Medicinal Chemistry p. 1423 - 1431 (2008)

Update date:2022-07-29

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Authors:

Joseph, Christine G.

Wilson, Krista R.

Wood, Michael S.

Sorenson, Nicholas B.

Phan, Dong V.

Xiang, Zhimin

Witek, Rachel M.

Haskell-Luevano, Carrie

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Article abstract of DOI:10.1021/jm701303z

The melanocortin system consists of five seven-transmembrane spanning G-protein coupled receptors (MC1-5) that are stimulated by endogenous agonists and antagonized by the only two known endogenous antagonists of GPCRs, agouti and agouti-related protein (

Full text of DOI:10.1021/jm701303z

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