Bioactivity of novel transition metal complexes of N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide

Article abstract of DOI:10.1016/j.ejmech.2007.04.017

Cu(II), Fe(III), and Mn(II) complexes of a novel ligand N′-[(4-methoxy)thiobenzoyl]benzoic acid hydrazide (H₂mtbh) have been synthesized and characterized by elemental analyses, IR, UV-vis, NMR, mass, EPR and Moessbauer spectroscopy. The results suggest a square planar structure for [Cu(Hmtbh)Cl] and [Cu(mtbh)] whereas an octahedral structure for [Mn(Hmtbh)₂] and [Fe(Hmtbh)(mtbh)]. Mn(II) and Fe(III) complexes were found to inhibit proliferation of HT29 cells. [Mn(Hmtbh)₂] and [Fe(Hmtbh)(mtbh)] inhibited proliferation of HT29 cells with half maximal inhibition (IC₅₀) of 8.15 ± 0.87 and 68.1 ± 4.8 μM, respectively, whereas H₂mtbh showed growth inhibition with IC₅₀ of 90.9 ± 7.8 μM and were able to inhibit NMT activity in vitro. Mn(II) and Fe(III) complexes inhibited NMT activity in a dose dependent manner with IC₅₀ values of 20 ± 2.2 and 60 ± 7.2 μM, respectively, whereas ligand (H₂mtbh) displayed IC₅₀ of 3.2 ± 0.5 mM.