Thromboxane Receptor Antagonism Combined with Thromboxane Synthase Inhibition. 2. Synthesis and Biological Activity of 8-(Benzenesulfonamido)-7-(3-pyridinyl)octanoic Acid and Related Compounds

DOI: 10.1021/jm00101a013

Source and publish data:

Journal of Medicinal Chemistry p. 4362 - 4365 (1992)

Update date:2022-08-03

Topics: Synthesis Biological Activity Related compounds

Authors:

Main, Alan J.

Goldstein, Robert

Cohen, David S.

Furness, Patricia

Lee, Warren

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Article abstract of DOI:10.1021/jm00101a013

A series of arylsulfonamido alkanoic acids substituted with a 3-pyridinyl group along the aliphatic chain were synthesized and tested in vitro for their ability to antagonize thromboxane A₂ (TxA₂) receptors and inhibit thromboxane sy

Full text of DOI:10.1021/jm00101a013

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Product name:8-(4-Methoxy-benzenesulfonylamino)-7-pyridin-3-yl-octanoic acid methyl ester

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