Journal of Organic Chemistry p. 2965 - 2969 (1986)
Update date:2022-08-02
Topics:
Broxton, Trevor J.
Wright, Sallyanne
Kinetic and mechanistic studies of the basic hydrolysis of several benzodiazepinone drugs have been carried out in the presence of micelles of cetyltrimethylammonium bromide (CTAB) and in aqueous solution.For diazepam, a change of mechanism from initial azomethine hydrolysis in water to initial amide hydrolysis in the presence of micelles of CTAB is indicated.For nimetazepam and N-benzylnitrazepam, initial amide hydrolysis was observed both in the presence of CTAB and in water.For the latter compounds, strong catalysis (50-100) of amide hydrolysis (phase 1) by micelles of CTAB was observed, while azomethine hydrolysis (phase 2) was only very weakly catalyzed (3-4-fold).For diazepam, the catalysis was smaller (9-18-fold), but this was accompanied by a mechanistic change so that here the actual catalysis of amide hydrolysis is masked.
View MoreAngelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Shanghai Hongbang Medical Technology CO.,. Ltd
Contact:13671516988 /18917636693
Address:Room1, No67 Building, Yongde Road369, Wujing Town, Minhang Districy, Shanghai CIty, China.
HaiNan Periwinkle Pharmaceutical Co.,Ltd.
website:http://www.cchpharm.com/en/index.html
Contact:020-82208978
Address:Gongye road,Wuzhishan city,HaiNan province
Anhui Dexinjia Biopharm Co., Ltd
Contact:+86-531-82375818
Address:9 Hexie Road, kaifaqu, Taihe
Contact:+86-0760-85282375
Address:zhongjing road,zhongshan torch hi-tech industrial development zone
Doi:10.3184/030823407X210901
(2007)Doi:10.1021/ja00274a074
(1986)Doi:10.1021/jm0509703
(2006)Doi:10.1016/j.tet.2008.02.028
(2008)Doi:10.1246/bcsj.59.493
(1986)Doi:10.1016/0008-6215(85)85007-2
(1985)