Bioorganic and Medicinal Chemistry Letters p. 2455 - 2458 (2008)
Update date:2022-09-26
Topics:
Reid, Caroline M.
Ebikeme, Charles
Barrett, Michael P.
Patzewitz, Eva-Maria
Mueller, Sylke
Robins, David J.
Sutherland, Andrew
A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes was synthesised and the compounds were tested for their ability to kill trypanosome and malaria parasites. Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen.
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