CAS No.50-01-1,Guanidine hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	50-01-1
Name:	Guanidine hydrochloride
Article Data:	32

Formula:	CH₅N₃.HCl
Molecular Weight:	95.5317
Synonyms:	Guanidine,monohydrochloride (8CI,9CI);Buffer AL;Guanidine chloride;Guanidinehydrochloride;Guanidinium chloride;Guanidinium hydrochloride;
EINECS:	200-002-3
Density:	1.18 g/mL at 25 °C(lit.)
Melting Point:	180-185 °C(lit.)
Boiling Point:	132.9 °C at 760 mmHg
Flash Point:	34.2 °C
Solubility:	2280 g/L (20 °C) in water
Appearance:	White cryst. powder
Hazard Symbols:	Xn, Xi
Risk Codes:	22-36/38
Safety:	26-36-22
PSA:	75.89000
LogP:	1.14090

Synthetic route

: guanidinium trinitromethanide

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether at 0℃; Product distribution;	78%

: 1674-62-0
N1-methyl biguanide hydrochloride

A: 420-04-2
CYANAMID

B: 471-29-4
1-methylguanidine

C: 50-01-1
guanidine hydrochloride

D: 4674-68-4
methylcyanamide

Conditions

Conditions	Yield
bei der thermischen Zersetzung;

...Expand

: 57-13-6
urea

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
With aluminium trichloride; ammonia at 300℃;

: N-methylguanidine hydrochloride

: 2-amino-4,5-dihydro-4,5-dihydroxyimidazolium chloride

A: 50-01-1
guanidine hydrochloride

B: 1-methyl-2-amino-4,5-dihydro-4,5-dihydroxyimidazolinium chloride

Conditions

Conditions	Yield
In chloroform-d1 Equilibrium constant; pH 8;

...Expand

: 127099-85-8, 780722-26-1
N-Cyanoguanidine

aqueous ammonium chloride: aqueous ammonium chloride

A: 645-93-2
ammelide

B: 50-01-1
guanidine hydrochloride

C: 56-03-1
BIGUANIDE

Conditions

Conditions	Yield
at 150℃;

...Expand

: 56-23-5
tetrachloromethane

: 7664-41-7
ammonia

: 7553-56-2
iodine

copper: copper

A: 74-90-8
hydrogen cyanide

B: 460-19-5
ethanedinitrile

C: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
at 140℃;

...Expand

: 64-17-5
ethanol

: 420-04-2
CYANAMID

: ammonium chloride

: 50-01-1
guanidine hydrochloride

Conditions

Conditions	Yield
at 100℃;

...Expand

: 7647-01-0
hydrogenchloride

: 509-14-8
tetranitromethane

nickel coated zinc: nickel coated zinc

A: ammonium chloride

B: 50-01-1
guanidine hydrochloride

...Expand

: 7664-41-7
ammonia

: 31407-74-6
O-ethyl-isourea hydrochloride

: 50-01-1
guanidine hydrochloride

: thiocarbimidoic acid O-ethyl ester-S-methyl ester; hydrochloride

concentrated alcoholic ammonia: concentrated alcoholic ammonia

: 50-01-1
guanidine hydrochloride

Raw Materials

7664-41-7

57-13-6

56-23-5

Downstream Products

Total:227 Page 1 of 6 1 2 3 4 5 6 Next>>

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Chemistry

Product Name: Guanidine hydrochloride (50-01-1)

Molecular Formula: CH₆ClN₃
Molecular Weight: 95.53g/mol
Mol File: 50-01-1.mol
Einecs: 200-002-3
Melting Point: 180-185 °C(lit.)
Boiling point: 132.9 °C at 760 mmHg
Storage Temperature: Store at RT.
Flash Point: 34.2 °C
Density: 1.18 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.465
Water Solubility: 2280 g/L (20 ºC)
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates; Miscellaneous Biochemicals
Synonyms of Guanidine hydrochloride (50-01-1): guanidine,monohydrochloride ; guanidinechloride ; guanidinemonohydrochloride ; guanidiniumhydrochloride ; usafek-749 ; carbamidine hydrochloride ; iminourea hydrochloride ; guanidinium chloride .

Uses

Guanidine hydrochloride (50-01-1) is mainly used as a drug intermediate, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and folic acid an important raw material. It also can be used as medicine, pesticide, dyes and other organic synthesis intermediates. Can be used to synthesis of 2 - amino-pyrimidine, 2 - amino -6 - methyl-pyrimidine, 2 - amino -4,6 - dimethyl-pyrimidine, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and other sulfa drugs, intermediates. Guanidine (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4 - 2-amino -6 - hydroxy-pyrimidine, folic acid used for synthesis of anti-anemia drugs. Also be used as synthetic anti-static agent.

Production

Double cyanide-ammonia and ammonium salt (ammonium chloride) as raw materials in the 170-230 ℃ melt under the reaction of guanidine hydrochloride were crude, after refining was finished.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	subcutaneous	200mg/kg (200mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
guinea pig	LDLo	intraarterial	500mg/kg (500mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig	LDLo	intravenous	500mg/kg (500mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig	LDLo	subcutaneous	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
mammal (species unspecified)	LDLo	oral	300mg/kg (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931.
mouse	LD50	intraperitoneal	500mg/kg (500mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	oral	571mg/kg (571mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: IRRITABILITY	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 598, 1993.
rabbit	LD	skin	> 2gm/kg (2000mg/kg)		Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 596, 1993.
rat	LD50	oral	475mg/kg (475mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	National Technical Information Service. Vol. AD-A165-747,
rat	LDLo	subcutaneous	404mg/kg (404mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 251, 1926.

Safety Profile

Safety Information of Guanidine hydrochloride (50-01-1):
Hazard Codes: Xn,Xi
Risk Statements: 22-36/38
22: Harmful if swallowed
36: Irritating to the eyes
38: Irritating to the skin
Safety Statements: 26-36-22
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing