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| CAS No.: | 50-01-1 |
|---|---|
| Name: | Guanidine hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | CH5N3.HCl |
| Molecular Weight: | 95.5317 |
| Synonyms: | Guanidine,monohydrochloride (8CI,9CI);Buffer AL;Guanidine chloride;Guanidinehydrochloride;Guanidinium chloride;Guanidinium hydrochloride; |
| EINECS: | 200-002-3 |
| Density: | 1.18 g/mL at 25 °C(lit.) |
| Melting Point: | 180-185 °C(lit.) |
| Boiling Point: | 132.9 °C at 760 mmHg |
| Flash Point: | 34.2 °C |
| Solubility: | 2280 g/L (20 °C) in water |
| Appearance: | White cryst. powder |
| Hazard Symbols: |
 Xn,  Xi
|
| Risk Codes: | 22-36/38 |
| Safety: | 26-36-22 |
| PSA: | 75.89000 |
| LogP: | 1.14090 |
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- 50-01-1
guanidine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride In diethyl ether at 0℃; Product distribution; | 78% |
- 1674-62-0
N1-methyl biguanide hydrochloride
A
- 420-04-2
CYANAMID
B
- 471-29-4
1-methylguanidine
C
- 50-01-1
guanidine hydrochloride
D
- 4674-68-4
methylcyanamide
| Conditions | Yield |
|---|---|
| bei der thermischen Zersetzung; |
| Conditions | Yield |
|---|---|
| With aluminium trichloride; ammonia at 300℃; |
A
- 50-01-1
guanidine hydrochloride
| Conditions | Yield |
|---|---|
| In chloroform-d1 Equilibrium constant; pH 8; |
- 127099-85-8, 780722-26-1
N-Cyanoguanidine
A
- 645-93-2
ammelide
B
- 50-01-1
guanidine hydrochloride
C
- 56-03-1
BIGUANIDE
| Conditions | Yield |
|---|---|
| at 150℃; |
- 56-23-5
tetrachloromethane
- 7664-41-7
ammonia
- 7553-56-2
iodine
A
- 74-90-8
hydrogen cyanide
B
- 460-19-5
ethanedinitrile
C
- 50-01-1
guanidine hydrochloride
| Conditions | Yield |
|---|---|
| at 140℃; |
| Conditions | Yield |
|---|---|
| at 100℃; |
- 50-01-1
guanidine hydrochloride
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Chemistry
Product Name: Guanidine hydrochloride (50-01-1)
Molecular Formula: CH6ClN3
Molecular Weight: 95.53g/mol
Mol File: 50-01-1.mol
Einecs: 200-002-3
Melting Point: 180-185 °C(lit.)
Boiling point: 132.9 °C at 760 mmHg
Storage Temperature: Store at RT.
Flash Point: 34.2 °C
Density: 1.18 g/mL at 25 °C(lit.)
Refractive index: n20/D 1.465
Water Solubility: 2280 g/L (20 ºC)
Sensitive: Hygroscopic
Product Categories: Pharmaceutical Intermediates; Miscellaneous Biochemicals
Synonyms of Guanidine hydrochloride (50-01-1): guanidine,monohydrochloride ; guanidinechloride ; guanidinemonohydrochloride ; guanidiniumhydrochloride ; usafek-749 ; carbamidine hydrochloride ; iminourea hydrochloride ; guanidinium chloride .
Uses
Guanidine hydrochloride (50-01-1) is mainly used as a drug intermediate, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and folic acid an important raw material. It also can be used as medicine, pesticide, dyes and other organic synthesis intermediates. Can be used to synthesis of 2 - amino-pyrimidine, 2 - amino -6 - methyl-pyrimidine, 2 - amino -4,6 - dimethyl-pyrimidine, is to create sulfadiazine, sulfa-methyl pyrimidine, sulfamethazine and other sulfa drugs, intermediates. Guanidine (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4 - 2-amino -6 - hydroxy-pyrimidine, folic acid used for synthesis of anti-anemia drugs. Also be used as synthetic anti-static agent.
Production
Double cyanide-ammonia and ammonium salt (ammonium chloride) as raw materials in the 170-230 ℃ melt under the reaction of guanidine hydrochloride were crude, after refining was finished.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | subcutaneous | 200mg/kg (200mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. | |
| guinea pig | LDLo | intraarterial | 500mg/kg (500mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. | |
| guinea pig | LDLo | intravenous | 500mg/kg (500mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928. | |
| guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935. | |
| mammal (species unspecified) | LDLo | oral | 300mg/kg (300mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Industrial Hygiene. Vol. 13, Pg. 87, 1931. |
| mouse | LD50 | intraperitoneal | 500mg/kg (500mg/kg) | National Technical Information Service. Vol. AD277-689, | |
| mouse | LD50 | oral | 571mg/kg (571mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: IRRITABILITY | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 598, 1993. |
| rabbit | LD | skin | > 2gm/kg (2000mg/kg) | Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 596, 1993. | |
| rat | LD50 | oral | 475mg/kg (475mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | National Technical Information Service. Vol. AD-A165-747, |
| rat | LDLo | subcutaneous | 404mg/kg (404mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 28, Pg. 251, 1926. |
Safety Profile
Safety Information of Guanidine hydrochloride (50-01-1):
Hazard Codes: Xn,Xi.gif){kind=small}
Risk Statements: 22-36/38
22: Harmful if swallowed
36: Irritating to the eyes
38: Irritating to the skin
Safety Statements: 26-36-22
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing