SYNTHESIS OF THE RACEMIC AND OPTICALLY ACTIVE FORMS OF GIZZEROSINE, THE INDUCER OF GIZZARD EROSION IN CHICKS

Article abstract of DOI:10.1016/S0040-4020(01)96782-1

The racemate end both the (R)- and (S)-forms of gizzerosine <2-amino-9-(4-imidazolyl)-7-azanonanoic acid> were synthesised, and the (S)-isomer was identified as the toxic substance in fish meal causing severe gizzard erosion (black vomit) in chicks.