Bioorganic and Medicinal Chemistry Letters p. 3158 - 3162 (2008)
Update date:2022-07-29
Topics:
Eckhardt, Matthias
Hauel, Norbert
Himmelsbach, Frank
Langkopf, Elke
Nar, Herbert
Mark, Michael
Tadayyon, Moh
Thomas, Leo
Guth, Brian
Lotz, Ralf
Systematic variations of the xanthine scaffold in close analogs of development compound BI 1356 led to the class of 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones which provided, after substituent screening, a series of highly potent DPP-4 inhibitors.
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