Inhibition of Cathepsin D by Substrate Analogues Containing Statine and by Analogues of Pepstatin

DOI: 10.1021/jm00162a015

Source and publish data:

Journal of Medicinal Chemistry p. 2519 - 2524 (1986)

Update date:2022-07-30

Topics:

Authors:

Agarwal, Nirankar S.

Rich, Daniel H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00162a015

Five new cathepsin D inhibitors were synthesized and tested as inhibitors of bovine cathepsin D.The compounds were derived by replacing a Phe-Phe dipeptidyl unit of a good cathepsin D substrate, Boc-Phe-Leu-Ala-Phe-Phe-Val-Leu-OR, with statine ((3S,4S)-4-

Full text of DOI:10.1021/jm00162a015

Products guided by the article

Product name:Boc-(S,S)-Sta-Phe-Val-Leu-OMe

Cas No:104465-45-4

R&D Labs maybe for 104465-45-4

Tianjin Boron PharmaTech Co.,Ltd.(expird)

Contact:86-022-59845187

Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
Sino-Japan Chemical Co., Ltd.

website:http://www.sjc.com.tw

Contact:(886) 2-2396-6223

Address:14Fl., No. 99. Sec. 2, Jen Ai Road
changsha chenjin chemical technology co.,LtD(expird)

Contact:86-731-84451263

Address:Room 201/217-218, 101 Jingyuan Electronic Technology Co.,Ltd. Testing Center, No.69, Lufeng Road, High-tech Development Zone, Changsha, China
Suzhou Credit International Trading Co., Ltd

Contact:+86-512-65398039

Address:Qingdeng, Hightech. District, Suzhou
HAORUI ENTERPRISES LLC

Contact:(1) 206-3550089

Address:5115 NE 8TH PL, Renton, WA 98059 USA

Relevant to this article

Sequential Claisen rearrangement and intramolecular Heck reaction as a route to medium-ring oxacycle-fused heterocycles

Doi:10.1055/s-2008-1072719
(2008)
The Synthesis of Dihydro-1,2,3,5-thiatriazole-1,1-dioxides, II

Doi:10.1007/BF00811103
(1985)
Resolution and Assignment of Absolute Configuration to the Enantiomers of Anastrephin and Epianastrephin and Their Analogues

Doi:10.1021/jo00375a016
(1986)
Preparation of σ- and π-allylcopper(III) intermediates in S _N2 and S_N2′ reactions of organocuprate(I) reagents with allylic substrates

Doi:10.1021/ja801186c
(2008)
A DIC mediated expeditious small library synthesis and biological activity of thiazolidin-4-one and 1,3-thiazinan-4-one derivatives

Doi:10.1002/jhet.429
(2010)
Hybrid silica materials derived from Hoveyda-Grubbs ruthenium carbenes. Electronic effects of the nitro group on the activity and recyclability as diene and enyne metathesis catalysts

Doi:10.1016/j.tet.2008.04.113
(2008)

Article Doi