Inhibition of Cathepsin D by Substrate Analogues Containing Statine and by Analogues of Pepstatin

DOI: 10.1021/jm00162a015

Source and publish data:

Journal of Medicinal Chemistry p. 2519 - 2524 (1986)

Update date:2022-07-30

Topics:

Authors:

Agarwal, Nirankar S.

Rich, Daniel H.

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Article abstract of DOI:10.1021/jm00162a015

Five new cathepsin D inhibitors were synthesized and tested as inhibitors of bovine cathepsin D.The compounds were derived by replacing a Phe-Phe dipeptidyl unit of a good cathepsin D substrate, Boc-Phe-Leu-Ala-Phe-Phe-Val-Leu-OR, with statine ((3S,4S)-4-

Full text of DOI:10.1021/jm00162a015

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