Reaction of Phosphorus Pentasulfide with Organolithiums. An In Situ Reagent for the Preparation of Thiolactams

Article abstract of DOI:10.1055/s-1987-27871

Phosphorus pentasulfide reacts under mild conditions with four equivalents of n-butyllithium, methyllithium or phenyllithium giving solutions in tetrahydrofuran.The new reagents in situ convert lactams to thiolactams and show significant selectivity in the type of reactive lactams.