Hock cleavage of cholesterol 5α-hydroperoxide: An ozone-free pathway to the cholesterol ozonolysis products identified in arterial plaque and brain tissue

DOI: 10.1021/ja804162d

Source and publish data:

Journal of the American Chemical Society p. 12224 - 12225 (2008)

Update date:2022-07-31

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Authors:

Brinkhorst, Johan

Nara, Susheel J.

Pratt, Derek A.

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Article abstract of DOI:10.1021/ja804162d

Cholesterol 5α-hydroperoxide, the major product of ¹O₂-oxidation of cholesterol, readily undergoes acid-catalyzed (Hock) cleavage of the C5-C6 bond to yield the 5,6-secosterol ketoaldehyde and the product of its intramolecular aldoli

Full text of DOI:10.1021/ja804162d

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