A Chemical Model of Thymidylate Synthetase. Formation of a Thymine Derivative via an Exocyclic Methylene Intermediate

DOI: 10.1039/c39850001229

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1229 - 1230 (1985)

Update date:2022-08-04

Topics:

Authors:

Meij, Paul F. C. van der

Lohmann, Ruth D.

Waard, Eduard R. de

Chen, Tjoe B. R. A.

Pandit, Upendra K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39850001229

Reaction of 6-aminouracil derivatives with imidazolidines (methylenetetrahydrofolate models), in the presence of acid, gives an exocyclic methylene intermediate which reacts with nucleophiles present in the mixture or can be reduced to a thymine derivative.

Full text of DOI:10.1039/c39850001229

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:N-{2-[2,4-Bis-(6-amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

Cas No:105159-19-1

R&D Labs maybe for 105159-19-1

AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
shanghai jiuling chemical co.,ltd.

Contact:+86-21-50387295

Address:Zaozhuang Road, Pudong, Shanghai City. China
Rudong Zhenfeng Yiyang Chemical Co., Ltd.

Contact:0513-84573047

Address:South Fengli Town, Rudong County, Jiangsu Province, China
HAORUI ENTERPRISES LLC

Contact:(1) 206-3550089

Address:5115 NE 8TH PL, Renton, WA 98059 USA
Shandong united-rising pharmaceutical cooperation.,ltd.

Contact:008653187965009

Address:171No., Jing5 Road, Shizhong District, Jinan, China

Relevant to this article

Synthesis and characterisation of some [M(C₃S₅)₂]^n- complexes (M = Ni, Pd, Pt). Single crystal structure of [PPN][Ni(C₃S₅)₂] · MeOH

Doi:10.1016/S0277-5387(97)00131-9
(1997)
Doi:10.1016/S0040-4020(01)99245-2
(1963)
Novel insight in structure-activity relationship and bioanalysis of P-glycoprotein targeting highly potent tetrakishydroxymethyl substituted 3,9-diazatetraasteranes

Doi:10.1021/jm800480y
(2008)
3β-Hydroxysialic acid glycosides. I. Calcium-binding ability and chemical and enzymatic stabilities

Doi:10.1248/cpb.40.2728
(1992)
(Halogenomethyl)phenyl &α-D-Glucopyranosides as Enzyme-activated Irreversible Inhibitors of Yeast &α-Glucosidase and Potential Anti-HIV Agents

Doi:10.1039/P19950000027
(1995)
Toward chemical libraries of annonaceous acetogenins. Total synthesis of trilobacin

Doi:10.1021/jo961286m
(1996)

Article Doi