A Chemical Model of Thymidylate Synthetase. Formation of a Thymine Derivative via an Exocyclic Methylene Intermediate

DOI: 10.1039/c39850001229

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1229 - 1230 (1985)

Update date:2022-08-04

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Authors:

Meij, Paul F. C. van der

Lohmann, Ruth D.

Waard, Eduard R. de

Chen, Tjoe B. R. A.

Pandit, Upendra K.

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Article abstract of DOI:10.1039/c39850001229

Reaction of 6-aminouracil derivatives with imidazolidines (methylenetetrahydrofolate models), in the presence of acid, gives an exocyclic methylene intermediate which reacts with nucleophiles present in the mixture or can be reduced to a thymine derivative.

Full text of DOI:10.1039/c39850001229

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