A novel enantioselective synthetic route to omuralide analogues with the potential for species selectivity in proteasome inhibition.

Article abstract of DOI:10.1021/ol015757p

[reaction in text] The building blocks shown can be combined for an enantioselective construction of the simplified omuralide analogue 4 in nine steps, with the use of (R)-atrolactic acid as a recoverable chiral controller.