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3-(Benzodioxan-2-ylmethoxy)-2,6-difluorobenzamides bearing hydrophobic substituents at the 7-position of the benzodioxane nucleus potently inhibit methicillin-resistant Sa and Mtb cell division

DOI: 10.1016/j.ejmech.2016.03.068

Source and publish data:

European Journal of Medicinal Chemistry p. 227 - 243 (2016)

Update date:2022-08-03

Topics:

Authors:

Straniero, ValentinaStraniero, Valentina

Pallavicini, MarcoPallavicini, Marco

Chiodini, GiuseppeChiodini, Giuseppe

Zanotto, CarloZanotto, Carlo

Volontè, LucaVolontè, Luca

Radaelli, AntoniaRadaelli, Antonia

Bolchi, CristianoBolchi, Cristiano

Fumagalli, LauraFumagalli, Laura

Sanguinetti, MaurizioSanguinetti, Maurizio

Menchinelli, GiuliaMenchinelli, Giulia

Delogu, GiovanniDelogu, Giovanni

Battah, BasemBattah, Basem

De Giuli Morghen, CarloDe Giuli Morghen, Carlo

Valoti, ErmannoValoti, Ermanno

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Article abstract of DOI:10.1016/j.ejmech.2016.03.068

Lipophilic substituents at benzodioxane C (7) of 3-(benzodioxan-2-ylmethoxy)-2,6-difluorobenzamide improve the antibacterial activity against methicillin-resistant Staphylococcus aureus strains to MIC values in the range of 0.2-2.5 μg/mL, whereas hydrophi

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Full text of DOI:10.1016/j.ejmech.2016.03.068

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