Tetrahedron p. 4789 - 4798 (1993)
Update date:2022-07-29
Topics:
Patterson, John W.
A new synthesis of mycophenolic acid 1, has been accomplished using silyloxy-1,3-cyclohexadiene 9 which undergoes cycloaddition to dimethyl acetylenedicarboxylate and subsequent elimination of ethylene (Alder-Rickert reaction) to give the trisubstituted dimethyl phthalate 11. After conversion of 11 to phthalide 16, the (E)-4-methyl-4-hexenoic acid side-chain was constructed via an orthoester Claisen rearrangement using allylic alcohol 19 and triethyl orthoacetate.
View MoreContact:86-21-57725962
Address:shanghai
Shanghai Longjin Metallic Material Co., Ltd.
website:http://www.shlongjin.cn/
Contact:021-56517503,56502257
Address:No.16, Lane 555, Chengyin Road, Shanghai
Contact:852-27701081
Address:Room 2509, New Tech Plaza, 34 Tai Yau St., San Po Kong, HK
Contact:86-27-84888681
Address:Wuhan economic & technology development zone
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Contact:86-180510-83338
Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Doi:10.1021/ja00241a043
(1987)Doi:10.1002/ejic.201800359
(2018)Doi:10.1016/j.jorganchem.2008.08.024
(2008)Doi:10.1016/j.tet.2008.07.101
(2008)Doi:10.1021/acs.joc.5b00945
(2015)Doi:10.1002/anie.201912907
(2020)
