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| CAS No.: | 113507-06-5 |
|---|---|
| Name: | Moxidectin |
| Molecular Structure: | |
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| Formula: | C37H53NO8 |
| Molecular Weight: | 639.83 |
| Synonyms: | MilbemycinB, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-,[6R,23E,25S(E)]-;Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)- (9CI);23-Methoxime-LL-F 28249a;CL 301423;ProHeart 6;Quest;Quest (parasiticide);Vetdectin Oral Drench;Milbemycin B,5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-buten-1-yl)-6,28-epoxy-23-(methoxyimino)-,(6R,23E,25S)-; |
| EINECS: | 635-129-7 |
| Density: | 1.23 g/cm3 |
| Melting Point: | 132 °C |
| Boiling Point: | 790 ºC at 760 mmHg |
| Flash Point: | 431.6 ºC |
| Appearance: | Appearance White or pale yellow, amorphous powder |
| Hazard Symbols: | T,N |
| Risk Codes: | 25-50 |
| Safety: | 45-61-24/25 |
| PSA: | 116.04000 |
| LogP: | 5.72890 |
23-oxynemadectin
moxidectin
| Conditions | Yield |
|---|---|
| With N-methoxylamine hydrochloride; sodium acetate In methanol at -10 - 0℃; for 8h; | 88.6% |
| Conditions | Yield |
|---|---|
| With sodium acetate In methanol; water for 1h; Ambient temperature; | 80% |
| With sodium acetate In methanol at -15℃; for 0.5h; | |
| Stage #1: N-methoxylamine hydrochloride; 23-oxynemadectin With sodium acetate; acetic acid In 1,4-dioxane at 20℃; for 10h; Inert atmosphere; Stage #2: With toluene-4-sulfonic acid In methanol at 0℃; for 4h; Temperature; Reagent/catalyst; | 0.015 mol |
C38H52O9
moxidectin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: de-esterification 2: 80 percent / NaOAc / methanol; H2O / 1 h / Ambient temperature View Scheme |
C38H54O9
moxidectin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: pyridinium dichromate / or Swern oxidation 2: de-esterification 3: 80 percent / NaOAc / methanol; H2O / 1 h / Ambient temperature View Scheme |
moxidectin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 4-methyl-morpholine; triethylamine / dichloromethane / 20 - 25 °C 2: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 3: sodium acetate / dichloromethane; methanol / -13 °C 4: sodium hydroxide; methanol / dichloromethane / -13 °C View Scheme | |
| Multi-step reaction with 4 steps 1: 4-methyl-morpholine; triethylamine / dichloromethane / 20 - 25 °C 2: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 3: sodium hydroxide; methanol / dichloromethane / -13 °C / Inert atmosphere 4: sodium acetate / methanol / 0.5 h / -15 °C View Scheme |
moxidectin
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 2: sodium acetate / dichloromethane; methanol / -13 °C 3: sodium hydroxide; methanol / dichloromethane / -13 °C View Scheme | |
| Multi-step reaction with 3 steps 1: O-phenyl phosphorodichloridate; triethylamine; Isopropyl acetate / dichloromethane; dimethyl sulfoxide / -25 - 35 °C 2: sodium hydroxide; methanol / dichloromethane / -13 °C / Inert atmosphere 3: sodium acetate / methanol / 0.5 h / -15 °C View Scheme |
moxidectin
moxidectin
| Conditions | Yield |
|---|---|
| With 2-Mercaptobenzothiazole In toluene Heating; |
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Molecular Structure of Moxidectin (CAS NO.113507-06-5):
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Systematic Name: (2aE,4E,4'Z,5'S,6R,6'S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(1E)-1,3-Dimethylbut-1-en-1-yl]-20,20b-dihydroxy-4'-(methoxyimino)-5',6,8,19-tetramethyl-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetrad ecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one
Molecular Weight: 639.81862 [g/mol]
Molecular Formula: C37H53NO8
XLogP3-AA: 4.3
H-Bond Donor: 2
H-Bond Acceptor: 9
Index of Refraction: 1.581
Molar Refractivity: 172.46 cm3
Molar Volume: 517.1 cm3
Surface Tension: 41.3 dyne/cm
Density: 1.23 g/cm3
Flash Point: 431.6 °C
Enthalpy of Vaporization: 130.93 kJ/mol
Boiling Point: 790 °C at 760 mmHg
Vapour Pressure: 7.61E-29 mmHg at 25 °C
storage temp.: 2-8 °C
Classification Code: Anthelmintics; Antinematodal Agents; Antiparasitic [veterinary]; Insecticides
Product Categories: Anthelmintic, antiparasitic.; METI - MZAntibiotics; MLSAnalytical Standards; Antibiotics; BacteriostaticAntibiotics; beta-Lactam StructureAlphabetic; Chemical Structure; Chromatography; M; Pharmacology Standards; Principle
Moxidectin (CAS NO.113507-06-5) is a parasiticide used for the prevention and control of heartworm and intestinal worms, and can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. It is also used for the prevention of red mite in caged birds. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions.
Safety Information of Moxidectin (CAS NO.113507-06-5):
RIDADR: 2588
HazardClass: 6.1(b)
PackingGroup: III
Moxidectin (CAS NO.113507-06-5), its Synonyms are (6R,25S)-5-O-Demethyl-28-deoxy-25-((E)-1,3-dimethyl-1-butenyl)-6,28-epoxy-23-oxomilbemycin B 23-(E)-(O-methyloxime) ; CL 301,423 ; Cydectin ; Milbemycin B, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S(E))- ; (2aE,4E,5'R,6R,6'S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-((E)-1,3-Dimethyl-1-butenyl)-5',6,6',7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5',6,8,19-tetramethylspiro(11,15-methano-2H,13H,17H-furo(4,3,2-pq)(2,6)benzodioxacyclooctadecin-13,2'-(2H)pyran)-4',17(3'H)-dione 4'-(E)-(O-methyloxime) .
