EFFICIENT SYNTHESIS OF 1-SUBSTITUTED 2,5-DICYANOPYRROLIDINES BY THE STRECKER REACTION USING SUCCINALDEHYDE AND PRIMARY AMINES, AND THEIR STEREOCHEMISTRY

Article abstract of DOI:10.3987/R-1986-10-2905

An efficient sequence proposed here for new synthesis of 1-substituted 2,5-dicyanopyrrolidines involves the simple Strecker reaction using succinaldehyde bis-sodium bisulfite and primary amines.Furthermore, their stereochemistry is also discussed.