70775-75-6

Basic information

• Product Name: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride
• Synonyms: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride;Octenidine hydrochloride;OCTENIDINE DIHYDROCHLORIDE;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride;N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride;N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride;ocenidine dihydrochloride;1-OctanaMine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2)
• CAS NO: 70775-75-6
• Molecular Formula: C₃₆H₆₂N₄*2ClH
• Molecular Weight: 623.82616
• EINECS: 274-861-8
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 70775-75-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 215-217℃
• Boiling Point: 609.3 °C at 760 mmHg
• Flash Point: 322.3 °C
• Appearance: /
• Density: 1.046[at 20℃]
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Soluble in dimethyl sulfoxide and methanol.
• Water Solubility: 14.2g/L at 20℃
• Stability: Hygroscopic
• Merck: 14,6754
• CAS DataBase Reference: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(70775-75-6)
• EPA Substance Registry System: N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride(70775-75-6)

Safety Data

• Hazardous Substances Data: 70775-75-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 70775-75-6 differently. You can refer to the following data:
1. Octenidine is an antiseptic (topical). Octenidine is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative.
2. Octenidine dihydrochloride is used as a antiseptic for skin, mucous Membranes and wounds.

Flammability and Explosibility

Notclassified

Synthetic route

1,10-bis-(4-chloropyridin-1 (4H)-yl)decane + n-octylamine hydrochloride (142-95-0) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
In N,N-dimethyl-formamide at 160℃; Inert atmosphere;	94.2%

1,10-dichlorodecane (2162-98-3) + 4-(octylamino)pyridine (64690-19-3) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
In acetic acid butyl ester for 12h; Reflux;	85.1%
In N,N-dimethyl-formamide at 120 - 180℃;	39%
In water

4-aminopyridine (504-24-5) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 80 °C / 2625.26 Torr 2: acetic acid butyl ester / 12 h / Reflux View Scheme

Octanal (124-13-0) → octenidine dihydrochloride (70775-75-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 80 °C / 2625.26 Torr 2: acetic acid butyl ester / 12 h / Reflux View Scheme

octenidine dihydrochloride (70775-75-6) → N,N'-(1,10 decanediyldi-1[4H]-pyridinyl-4-ylidene)-bis-(1-octanamine)

Conditions	Yield
With sodium hydroxide In water; toluene at 20 - 30℃;	14.5 g

Upstream product

• 124-13-0 Octanal 
• 504-24-5 4-aminopyridine 
• 142-95-0 n-octylamine hydrochloride 
• 2162-98-3 1,10-dichlorodecane 
• 64690-19-3 4-(octylamino)pyridine 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF N-ALKYL-4-PYRIDINAMINES

The present invention relates to an improved process for the synthesis of N-alkyl-4-pyridinamines comprising the catalytic hydrogenation of a precursor compound which is carried out in the presence of an acid.

Process for the preparation of bis(4-amino-1-pyridinium) alkanes

Process for the preparation of bis(4-amino-1-pyridinium)alkanes by reacting difunctionalized alkanes with 4-aminopyridines in water or a mixture of water and organic solvent.