A synthesis of substituted 2-pyrones by carbonylative cross-coupling-thermolysis of 4-halocyclobutenones with alkenyl-, aryl-, and heteroarylstannanes

Article abstract of DOI:10.1016/S0040-4020(01)87262-8

Palladium catalyzed carbonylative cross-coupling of 4-chloro-2,3-disubstituted-2-cyclobutenones with alkenyl-, aryl-, and heteroaryltin reagents and thermolysis provides a general method for the synthesis of 2,3,6-trisubstituted-2-pyrones. The reaction is