Optimized synthesis of LNA uracil nucleosides

DOI: 10.1016/j.tetlet.2008.09.165

Source and publish data:

Tetrahedron Letters p. 7168 - 7170 (2008)

Update date:2022-08-05

Topics:

Authors:

Santhosh Kumar

Kumar, Pawan

Sharma, Pawan K.

Hrdlicka, Patrick J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.tetlet.2008.09.165

A short, very high yielding, and practical synthesis of LNA uracil diol 6 has been developed from the easily accessible glycosyl donor 1. The concluding O3′-debenzylation of 5 resulted in significant reduction of the uracil moiety with many typical debenz

Full text of DOI:10.1016/j.tetlet.2008.09.165

Products guided by the article

Product name:(2R,3R,4S)-4-(benzyloxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5,5-bis(((methylsulfonyl)oxy)methyl)tetrahydrofuran-3-yl acetate

Cas No:1094603-21-0

R&D Labs maybe for 1094603-21-0

Jiangsu Wanlong Chemical Co., Ltd.

website:http://www.wanlongchem.com

Contact:+86-511-86810993 0086-511-8681 0888;

Address:Quanzhou Town, Danyang City, Jiangsu
Shandong Jusage Technology Co.,Ltd.

Contact:86-13406130167

Address:No.20,North Ride No.9 Road, Guangrao Economic Development Zone, Shandong Province
Xinjiang Fufeng Biotechnologies Co., Ltd.

Contact:+86-539-7287111

Address:GANQUANPU INDUSTRIAL PARK, ECONOMIC AND TECHNOLOGICAL DEVELOPMENT AREA (TOUTUNHE DISTRICT) OF URUMQI
Jintan City Mego Chemical Co., Ltd

Contact:+86-0519-82814387

Address:23# Dengguan Town, Jintan, Jiangsu Province, China
Beyond Pharmaceutical Co., Ltd

Contact:+86-571-8195-3185

Address:No. 13-1, Liansheng Road, Yuhang District

Relevant to this article

Doi:10.1021/ja01249a019
(1943)
Transformation of pyrazolo[4,3-c]isothiazoles into 3,4-disubstituted 1,2-isothiazoles

Doi:10.1002/jhet.5570230634
(1986)
Doi:10.1021/ja01495a024
(1960)
One-pot synthesis of fused tricyclic heterocycles with quaternary carbon stereocenter by sequential pauson-khand reaction and formal [3+3] cycloaddition

Doi:10.1002/chem.200801453
(2008)
Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, photodamage and antitumor cytotoxicity

Doi:10.1016/j.bmcl.2008.09.104
(2008)
An electron-transporting host material compatible with diverse triplet emitters used for highly efficient red- and green-electrophosphorescent devices

Doi:10.1039/b807954d
(2008)

Article Doi