CAS No.872-50-4,1-Methyl-2-pyrrolidinone Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	872-50-4
Name:	1-Methyl-2-pyrrolidinone
Article Data:	138
Cas Database

Formula:	C₅H₉NO
Molecular Weight:	99.1326
Synonyms:	2-Pyrrolidinone,1-methyl-;1-Methyl-5-pyrrolidinone;1-Methylazacyclopentan-2-one;1-Methylpyrrolidone;AgsolEx 1;M-Pyrol;Microposit 2001;N 0131;N-Methyl-2-ketopyrrolidine;N-Methyl-2-pyrrolidinone;N-Methyl-a-pyrrolidinone;N-Methylbutyrolactam;N-Methylpyrrolidone;NMP;NSC 4594;Pharmasolve;Pyrol M;SL 1332;N-Methyl-2-Pyrrolidone(NMP);N-methyl-pyrrolidone;
EINECS:	212-828-1
Density:	1.033
Melting Point:	-24 °C
Boiling Point:	201.999 °C at 760 mmHg
Flash Point:	86.111 °C
Solubility:	Water solubility: >=10 g/100 mL at 20 °C
Appearance:	colourless or light yellow liquid with an amine odour
Hazard Symbols:	T,Xi
Risk Codes:	45-65-36/38
Safety:	41
PSA:	20.31000
LogP:	0.17650

Synthetic route

: 96-48-0
4-butanolide

methylamine: methylamine

Conditions

Conditions	Yield
With water; ZSM-5 at 280℃;	99%
In water at 300℃; under 75007.5 Torr; Concentration;	99.9%
at 255℃; under 15001.5 Torr; for 3h;	98.2%

: 33693-57-1
3-bromo-1-methyl-pyrrolidin-2-one

: 872-50-4
1-methyl-pyrrolidin-2-one

Conditions

Conditions	Yield
With indium; water at 20℃; for 6h;	99%

: 120-94-5
1-Methylpyrrolidine

: 872-50-4
1-methyl-pyrrolidin-2-one

Conditions

Conditions	Yield
With 5.4 wt% Au/CeO2; water; oxygen In 1,4-dioxane at 80℃; under 760.051 Torr; for 3.5h; Catalytic behavior; Reagent/catalyst; Temperature; Concentration; Schlenk technique;	97%
With iodosylbenzene In water for 36h;	55%
With tert.-butylhydroperoxide; [Mn(GBOA)2(H2O)2](Cl)24H2O In acetonitrile at 50 - 55℃;	49.4%
With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); water; sodium hydroxide at 160℃; for 48h; Inert atmosphere; Schlenk technique;	22%
With water; oxygen at 80℃; under 760.051 Torr; for 24h; Green chemistry; regioselective reaction;	> 99 %Chromat.

: 1191-95-3
cyclobutanone

: 85462-16-4
N-Methyl-O-p-nitrophenylsulphonylhydroxylamine

: 872-50-4
1-methyl-pyrrolidin-2-one

Conditions

Conditions	Yield
In chloroform 1.) -78 deg C, 2.) 25 deg C;	96%
In chloroform at 25℃;	96%
In chloroform at 25℃; other ketones, also with ketals, other reagent, other solvent;	96%

: 96-48-0
4-butanolide

: 124-40-3
dimethyl amine

: 74-89-5
methylamine

: 75-50-3
trimethylamine

: 872-50-4
1-methyl-pyrrolidin-2-one

Conditions

Conditions	Yield
at 255℃; for 3h;	94.8%

...Expand

: 616-45-5
2-pyrrolidinon

: 124-38-9
carbon dioxide

: 872-50-4
1-methyl-pyrrolidin-2-one

Conditions

Conditions	Yield
With copper nanoparticles-decorated triazinetriamine derived porous organic polymer; polymethylhydrosiloxane In acetonitrile at 80℃; under 760.051 Torr; for 8h; Inert atmosphere;	94%

: 76128-61-5
1-(dimethylchlorosilylmethyl)-2-pyrrolidone

A: 872-50-4
1-methyl-pyrrolidin-2-one

B diisopropoxydimethylsilane: diisopropoxydimethylsilane

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol at 60℃; for 3h;	A 92% B 92%

1-Methyl-2,2-dipropoxy-pyrrolidine: 1-Methyl-2,2-dipropoxy-pyrrolidine

2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole: 79108-52-4
2-Benzyl-1,2,3,4,6,7,12,12a-octahydropyrazino<2',1':6,1>pyrido<3,4-b>indole

A: 872-50-4
1-methyl-pyrrolidin-2-one

B 2-Benzyl-7-propyl-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole: 2-Benzyl-7-propyl-1,2,3,4,6,7,12,12a-octahydro-pyrazino[1',2':1,6]pyrido[3,4-b]indole

Conditions

Conditions	Yield
In tetrahydrofuran at 35℃; for 6h;	A n/a B 90%

...Expand

: 79108-53-5
1-Methyl-2,2-dipropoxy-pyrrolidine

: 42021-34-1
Biriperone

A: 872-50-4
1-methyl-pyrrolidin-2-one

B: 79108-61-5
1-(4-Fluoro-phenyl)-4-(7-propyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one

Conditions

Conditions	Yield
In tetrahydrofuran at 35℃; for 6h;	A n/a B 90%

...Expand

: 42021-34-1
Biriperone

: 39650-82-3
2,2-dimethoxy-1-methylpyrrolidine

A: 872-50-4
1-methyl-pyrrolidin-2-one

B: 79108-56-8
1-(4-Fluoro-phenyl)-4-(7-methyl-3,4,6,7,12,12a-hexahydro-1H-pyrazino[1',2':1,6]pyrido[3,4-b]indol-2-yl)-butan-1-one

Conditions

Conditions	Yield
In tetrahydrofuran at 35℃; for 6h;	A n/a B 90%

...Expand

Raw Materials

1191-95-3

76128-61-5

5264-35-7

74-89-5

77-78-1

33693-57-1

110-16-7

60-29-7

Downstream Products

616-45-5

120-57-0

107-46-0

Total:384 Page 1 of 11 1 2 3 4 5 6 …11 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

DFG MAK: 19 ppm (80 mg/m³)

Specification

1-Methyl-2-pyrrolidinone, its cas register number is 872-50-4. It also can be called N-Methyl-2-pyrrolidinone ; N-Methyl-2-Pyrrolidone ; NMP ; and N-Methylpyrrolidone . It is hazardous, so the first aid measures and others should be known. In addition, N-methyl-pyrrolidone (CAS NO.872-50-4) could be stable at room temperature in closed containers under normal storage and handling conditions. It is not compatible with strong oxidizing agents, strong acids, strong bases, and you must not take it with incompatible materials, light, temperatures above 100 °C, exposure to moist air or water. And also prevent it to broken down into hazardous decomposition products: nitrogen oxides, carbon monoxide, carbon dioxide.

Physical properties about 1-Methyl-2-pyrrolidinone are: (1)ACD/LogP: -0.637; (2)ACD/LogD (pH 5.5): -0.64; (3)ACD/LogD (pH 7.4): -0.64; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 10.73; (7)ACD/KOC (pH 7.4): 10.73; (8)#H bond acceptors: 2; (9)Index of Refraction: 1.47; (10)Molar Refractivity: 26.852 cm³; (11)Molar Volume: 96.268 cm³; (12)Polarizability: 10.645 10-24cm³; (13)Surface Tension: 33.7919998168945 dyne/cm; (14)Density: 1.03 g/cm³; (15)Flash Point: 86.111 °C; (16)Enthalpy of Vaporization: 43.821 kJ/mol; (17)Boiling Point: 201.999 °C at 760 mmHg; (18)Vapour Pressure: 0.29899999499321 mmHg at 25°C

Preparation of 1-Methyl-2-pyrrolidinone: 1-Methyl-2-pyrrolidinone (CAS NO.872-50-4) can be derived by the reaction of Γ-butyrolactone with amine .

Uses of 1-Methyl-2-pyrrolidinone: 1-Methyl-2-pyrrolidinone is used as intermediate for the synthesis of pharmaceuticals, agrochemicals, plasticizers, textile auxiliaries, stabilizers. It is also widely used in oil refining, pigments and cleaning, high polymer synthesis, chemicals, insulation materials, etc.

When you are using this chemical, please be cautious about it as the following:
1. In case of fire and/or explosion do not breathe fumes
2. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
3. Avoid exposure - obtain special instruction before use

You can still convert the following datas into molecular structure:
(1)InChI=1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3;
(2)InChIKey=SECXISVLQFMRJM-UHFFFAOYSA-N;
(3)SmilesC1(=O)N(CCC1)C;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	intravenous	63300ug/kg (63.3mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse	LD50	intraperitoneal	3050mg/kg (3050mg/kg)	United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1087-0695,
mouse	LD50	intravenous	54500ug/kg (54.5mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
mouse	LD50	oral	5130mg/kg (5130mg/kg)	United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1087-0695,
rabbit	LD50	skin	8gm/kg (8000mg/kg)	Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 84, 1974.
rat	LCLo	inhalation	1gm/m3 (1000mg/m3)	National Technical Information Service. Vol. OTS0534725,
rat	LD50	intraperitoneal	2472mg/kg (2472mg/kg)	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat	LD50	intravenous	80500ug/kg (80.5mg/kg)	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 18, Pg. 922, 1987.
rat	LD50	oral	3914mg/kg (3914mg/kg)	Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat	LD50	subcutaneous	> 2gm/kg (2000mg/kg)	United States Patent Document. Vol. #4882359,
rat	LD50	unreported	7gm/kg (7000mg/kg)	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 408, 1969.

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