Preparations of chiral pyrrolidinebisphosphines bearing two different types of phosphino groups and their use in efficient catalytic asymmetric hydrogenation

DOI: 10.1248/cpb.42.481

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 481 - 488 (1994)

Update date:2022-08-05

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Authors:

Morimoto

Takahashi

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.42.481

Chiral pyrrolidinebisphosphine ligands, (2S-cis)-BCPM and (2S-cis)-BCPP, bearing two different types of phosphino groups, a dicyclohexylphosphino group and a diphenylphosphino group, were designed and prepared on the basis of our design concept for developing highly efficient ligands. The validity of the concept was confirmed experimentally in the asymmetric hydrogenation of ketopantolactone using neutral rhodium(I) complexes of BCPM. BCPP, BPPM, and BCCP. The rhodium(I) complex of (2S-cis)-BCPM was found to be the most effective catalyst (substrate/catalyst >ca. 10⁴, >90% ee (R)).

Full text of DOI:10.1248/cpb.42.481

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