Preparations of chiral pyrrolidinebisphosphines bearing two different types of phosphino groups and their use in efficient catalytic asymmetric hydrogenation

DOI: 10.1248/cpb.42.481

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 481 - 488 (1994)

Update date:2022-08-05

Topics:

Authors:

Morimoto

Takahashi

Achiwa Achiwa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.481

Chiral pyrrolidinebisphosphine ligands, (2S-cis)-BCPM and (2S-cis)-BCPP, bearing two different types of phosphino groups, a dicyclohexylphosphino group and a diphenylphosphino group, were designed and prepared on the basis of our design concept for developing highly efficient ligands. The validity of the concept was confirmed experimentally in the asymmetric hydrogenation of ketopantolactone using neutral rhodium(I) complexes of BCPM. BCPP, BPPM, and BCCP. The rhodium(I) complex of (2S-cis)-BCPM was found to be the most effective catalyst (substrate/catalyst >ca. 10⁴, >90% ee (R)).

Full text of DOI:10.1248/cpb.42.481

NII-Electronic Library Service

Products guided by the article

Product name:(2S-cis)-4-(dicyclohexylphosphino)-2-<(dicyclohexylphosphino)methyl>-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester

Cas No:110466-08-5

R&D Labs maybe for 110466-08-5

Synochem Ingredients Corp., Ltd.

Contact:+86-512-5636 2180

Address:Zhangjiagang Free Trade Zone
Hybio Pharmaceutica Co.,Ltd

Contact:+86 755 26588093

Address:No.9 Linkong West Street, Hengdian Street, Huangpi District, Wuhan City, China.
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd

Contact:+86 411 84674606

Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Linyi Shengxin Pharmaceutical R&D Co., Ltd

Contact:+86-18653953873

Address:West First of Yufeng Road, Yishui County
TIC Gums, Inc.

Contact:410-273-7300; 800-221-3953

Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA

Relevant to this article

Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity

Doi:10.1021/jm800927r
(2009)
Rhodium-catalyzed intramolecular cycloaddition of cyclopropene-ynes triggered by cabon-carbon bond cleavage

Doi:10.3987/COM-08-S(N)92
(2008)
A NEW TYPE OF PALLADIUM(0) COMPLEX HAVING BOTH ELECTRON-WITHDRAWING AND -DONATING SITES IN A LIGAND: 5,8-DIHYDRO- AND 5,8,9,10-TETRAHYDRO-1,4-NAPHTHOQUINONE COMPLEXES

Doi:10.1016/S0022-328X(00)81013-X
(1981)
Trifluoroethanol as a metal-free, homogeneous and recyclable medium for the efficient one-pot synthesis of α-amino nitriles and α-amino phosphonates

Doi:10.1016/j.tetlet.2008.10.106
(2009)
Studies on chemical constituents of antitumor fraction from Periploca sepium. IV. Structures of new pregnane glycosides, periplocosides D, E, L, and M

Doi:10.1248/cpb.36.2084
(1988)
Polymer solar cells based on diphenylmethanofullerenes with reduced sidechain length

Doi:10.1039/c0jm01160f
(2011)

Article Doi