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Guanidine thiocyanate
Cas No: 593-84-0
USD $ 2.0-2.0 / Kilogram 1 Kilogram 1-10 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Guanidine thiocyanate
Cas No: 593-84-0
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Factory Supply Guanidine Thiocyanate
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High purity CAS:593-84-0 Guanidine thiocyanate
Cas No: 593-84-0
USD $ 20.0-30.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Xi'an ZB Biotech Co., Ltd. Contact Supplier
Guanidine thiocyanate
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Low price with good quality Guanidine thiocyanate
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GUANIDINE THIOCYANATE
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Guanidine thiocyanate best quality cas 593-84-0
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USD $ 13.0-15.0 / Kilogram 1 Kilogram 5000 Metric Ton/Year Shanghai Sunwise Chemical Co., Ltd Contact Supplier
Guanidine thiocyanate
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593-84-0 Usage

Description

Guanidine thiocyanate is one of the cheapest and easiest to prepare of the guanidine salts. Guanidine Thiocyanate is an ultrapure, molecular biology grade reagent. It is free of detectable nuclease and protease activity and is a strong protein denaturant, as both the guanidinium cation and the thiocyanate anion are chaotropic agents. It is provided in one bottle containing 500 g. It is recommended for isolation of RNA, especially for tissues such as pancreas with high levels of RNase activity. In solution, it is known as guanidinium thiocyanate. Guanidine Thiocyanate is thoroughly tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.

Hazard

Irritant.

Uses

Potent protein denaturant used in isolation of intact DNA, RNA.

Uses

Guanidine thiocyanate has been used: ? for the lysis of colorectal adenocarcinoma cell line prior to RNA isolation ? as a PCR inhibitor in triplex mitochondrial DNA (mtDNA) qPCR assay

Toxicity evaluation

Guanidine thiocyanate is used commercially as a disinfectant and a general protein denaturant but its more common use is in the extraction of DNA and RNA in molecular biology. Нere are no reports of guanidine thiocyanate toxicity from oral ingestion. Toxicity of di??erent thiocyanate compounds other than guanidine thiocyanate has been described. Potassium thiocyanate was used over 50 years ago for the treatment of hypertension and its toxicity appears to cause a neurological disorder consisting of generalized weakness, delirium and a decrease level of consciousness. Reports of thiocyanate toxicity from nitroprusside use for hypertension in the setting of renal impairment/failure have also been reported as thiocyanate is renally cleared. In a fatal deliberate ingestion of a herbicide which contained ammonium thiocyanate and aminotriazole, a 54 year old man presented with coma and cardiovascular collapse although the relative contributions of the two herbicides to the clinical toxicity is unknown.

Biochem/physiol Actions

Guanidine thiocyanate is a denaturing agent and is used routinely in RNA isolation. It is used as a storage buffer for whole blood samples. Guanidine thiocyanate inactivates nucleases and is ideal for storing and freezing fecal samples for DNA studies. It is used in combination with phenol?chloroform in RNA extraction.

Uses

It is mainly used for biomedicine, chemical reagents. Guanidine thiocyanate is a potent protein denaturant (stronger than guanidine HCl) often used in the isolation of intact ribonucleic acid to eliminate RNase activity. RNase can recover activity after boiling, but is irreversibly inactivated in a 4 M solution of guanidine thiocyanate. Such solutions, to which the reducing agent b-mercaptoethanol is often added, are used to inactivate RNAse when isolating RNA from tissues that are rich in RNase, such as liver. Total nuclear and cytoplasmic RNA may be isolated this way. A protocol for extracting RNA with guanidine isothiocyanate has been published. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.

Chemical Properties

White cryst.powder
InChI:InChI=1/C2H4N4S/c3-1-7-6-2(4)5/h(H4,4,5,6)

593-84-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (G0360)  Guanidine Thiocyanate [for Biochemical Research]  >98.0%(T) 593-84-0 5g 130.00CNY Detail
TCI America (G0360)  Guanidine Thiocyanate [for Biochemical Research]  >98.0%(T) 593-84-0 25g 220.00CNY Detail
Alfa Aesar (B21250)  Guanidine thiocyanate, 99%    593-84-0 100g 690.0CNY Detail
Alfa Aesar (B21250)  Guanidine thiocyanate, 99%    593-84-0 500g 2774.0CNY Detail
Alfa Aesar (B21250)  Guanidine thiocyanate, 99%    593-84-0 2500g 11748.0CNY Detail

593-84-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Guanidine thiocyanate

1.2 Other means of identification

Product number -
Other names GUANIDINE RHODANIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:593-84-0 SDS

593-84-0Synthetic route

ammonium thiocyanate

ammonium thiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
In melt 55 part of dicyanodiamide reacted with 100 part of NH4SCN;90%
In melt 55 part of dicyanodiamide reacted with 100 part of NH4SCN;90%
2,4,6-triamino-s-triazine
108-78-1

2,4,6-triamino-s-triazine

ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

CYANAMID
420-04-2

CYANAMID

ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 100℃;
ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 190℃;
at 195 - 212℃;
ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

N-Cyanoguanidine
127099-85-8, 780722-26-1

N-Cyanoguanidine

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

carbon disulfide
75-15-0

carbon disulfide

urea
57-13-6

urea

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 250℃;
thiourea
17356-08-0

thiourea

A

hydrogen sulfide
7783-06-4

hydrogen sulfide

B

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

C

ammonia
7664-41-7

ammonia

D

CS2

CS2

Conditions
ConditionsYield
at 195 - 230℃; under 760 Torr; Reaktion des Gleigewichtsgemisches Thioharnstoff-Ammoniumrhodanid; Produkt5:HSCN;
at 173℃; under 60 Torr; Reaktion des Gleigewichtsgemisches Thioharnstoff-Ammoniumrhodanid; Produkt5:HSCN;
pyridine
110-86-1

pyridine

thiourea
17356-08-0

thiourea

A

hydrogen sulfide
7783-06-4

hydrogen sulfide

B

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

C

trithiocarbonate ammonium(?)

trithiocarbonate ammonium(?)

carbon disulfide
75-15-0

carbon disulfide

ammonia

ammonia

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 200 - 350℃;
carbon oxide sulfide
463-58-1

carbon oxide sulfide

ammonia

ammonia

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 250℃;
NH3

NH3

NH4SCN

NH4SCN

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 170 - 180℃;
thiourea
17356-08-0

thiourea

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
at 180.85℃; Kinetics; Further Variations:; Temperatures;
urea
57-13-6

urea

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
With hydrogen sulfide High Pressure; at 240 until 260°C; pressure 70 to 140 atm; equimolar amts. of educts;
With hydrogen sulfide High Pressure; at 240 until 260°C; pressure 70 to 140 atm; equimolar amts. of educts;
ammonium thiocyanate

ammonium thiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
heating over temp. of formation of (NH4)2CS;
byproducts: NH3, CS2; 220°C;
With ammonia; ammonium chloride 300°C;25-30
ammonium thiocyanate

ammonium thiocyanate

thiourea
17356-08-0

thiourea

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
heating; 180-218°C;
ammonium thiocyanate

ammonium thiocyanate

thiourea
17356-08-0

thiourea

A

ammonium salt of trithiocarbonic acid

ammonium salt of trithiocarbonic acid

B

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
In neat (no solvent) heating;
In neat (no solvent) heating;
ammonium thiocyanate

ammonium thiocyanate

A

ammonium salt of trithiocarbonic acid

ammonium salt of trithiocarbonic acid

B

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

Conditions
ConditionsYield
In neat (no solvent) heating to 160-185°C;
In neat (no solvent) heating to 160-185°C;
ammonium thiocyanate

ammonium thiocyanate

A

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

B

4,6-diamino-1,3,5-triazine-2(1H)-thione
767-17-9

4,6-diamino-1,3,5-triazine-2(1H)-thione

Conditions
ConditionsYield
In melt 120°C;
In melt 120°C;
methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate
55934-10-6

methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

3-amino-1,4-dihydroindeno[1,2-c]pyrazole-5-carboxylic acid

3-amino-1,4-dihydroindeno[1,2-c]pyrazole-5-carboxylic acid

Conditions
ConditionsYield
Stage #1: methyl 1-oxo-2,3-dihydro-1H-indene-4-carboxylate; guanidinium thiocyanate With lithium hexamethyldisilazane In tetrahydrofuran at 20℃;
Stage #2: With hydrazine hydrate; acetic acid In tetrahydrofuran for 12h; Reflux;
82%
N-(pent-4-enyl)aniline
42331-17-9

N-(pent-4-enyl)aniline

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

1-phenyl-2-(thiocyanatomethyl)pyrrolidine

1-phenyl-2-(thiocyanatomethyl)pyrrolidine

Conditions
ConditionsYield
With iodine In ethyl acetate at 50℃; for 8h;78%
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

triaminoguanidinium thiocyanate
27561-84-8

triaminoguanidinium thiocyanate

Conditions
ConditionsYield
With hydrazine In 1,4-dioxane; water for 5.08333h; Reflux;60%
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

4-(piperidine-1-carbonyl)-2,3-dihydro-1H-inden-1-one

4-(piperidine-1-carbonyl)-2,3-dihydro-1H-inden-1-one

(3-amino-1,4-dihydroindeno[1,2-c]pyrazol-5-yl)(piperidin-1-yl)methanone

(3-amino-1,4-dihydroindeno[1,2-c]pyrazol-5-yl)(piperidin-1-yl)methanone

Conditions
ConditionsYield
Stage #1: guanidinium thiocyanate; 4-(piperidine-1-carbonyl)-2,3-dihydro-1H-inden-1-one With lithium hexamethyldisilazane In tetrahydrofuran at 55℃; for 12h;
Stage #2: With hydrazine hydrate; acetic acid In tetrahydrofuran for 24h; Reflux;
54%
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

13,16,30,33,54,57,65,68,74,77,85,88-Dodecaoxa-10,19,27,36,51,60-hexaazadecacyclo-<21.19.19.810,19.827,36.851,60.13,44.14,62.121,25.138,42.145,49>-nonaconta-1,3(81),4,6,8,21,23,25(71),38,40,42,43,45,47,49-pentadecaen
123902-93-2

13,16,30,33,54,57,65,68,74,77,85,88-Dodecaoxa-10,19,27,36,51,60-hexaazadecacyclo-<21.19.19.810,19.827,36.851,60.13,44.14,62.121,25.138,42.145,49>-nonaconta-1,3(81),4,6,8,21,23,25(71),38,40,42,43,45,47,49-pentadecaen

C72H102N6O12*3CH5N3*3CHNS
123902-94-3

C72H102N6O12*3CH5N3*3CHNS

Conditions
ConditionsYield
In methanol; ethyl acetate for 0.5h; Heating;43%
diethyl 1,4-cyclohexanedione-2,5-dicarboxylate
787-07-5

diethyl 1,4-cyclohexanedione-2,5-dicarboxylate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

2,7-diamino-3,5,8,10-tetrahydro-pyrimido[4,5-g]quinazoline-4,9-dione

2,7-diamino-3,5,8,10-tetrahydro-pyrimido[4,5-g]quinazoline-4,9-dione

Conditions
ConditionsYield
With sodium ethanolate
1,8-diaminooctan
373-44-4

1,8-diaminooctan

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

1,8-Diguanidinooctane
19010-48-1

1,8-Diguanidinooctane

Conditions
ConditionsYield
at 125 - 150℃;
Ethyl isothiocyanate
542-85-8

Ethyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

1-ethyl-3-formamidinothiocarbamide
44830-57-1

1-ethyl-3-formamidinothiocarbamide

Conditions
ConditionsYield
With sodium ethanolate
diaminodecane
646-25-3

diaminodecane

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N,N'''-1,10-decanediylbisguanidine
111-23-9

N,N'''-1,10-decanediylbisguanidine

Conditions
ConditionsYield
at 125 - 150℃;
With ammonia; water at 80 - 120℃;
With water at 120 - 140℃;
n-Propyl isothiocyanate
628-30-8

n-Propyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

sodium ethanolate
141-52-6

sodium ethanolate

1-amidino-3-propylthiourea
39140-29-9

1-amidino-3-propylthiourea

n-Propyl isothiocyanate
628-30-8

n-Propyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

1-amidino-3-propylthiourea
39140-29-9

1-amidino-3-propylthiourea

Conditions
ConditionsYield
With sodium ethanolate
isobutyl isothiocyanate
591-82-2

isobutyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N-carbamimidoyl-N'-isobutyl-thiourea

N-carbamimidoyl-N'-isobutyl-thiourea

Conditions
ConditionsYield
With sodium ethanolate
2-(diethoxymethylene)malononitrile
17618-65-4

2-(diethoxymethylene)malononitrile

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

2,4-diamino-6-ethoxy-pyrimidine-5-carbonitrile
18340-59-5

2,4-diamino-6-ethoxy-pyrimidine-5-carbonitrile

Conditions
ConditionsYield
With methanol; sodium methylate
diethyl oxalpropionate
759-65-9

diethyl oxalpropionate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

2-amino-5-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester

2-amino-5-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
(als Natrium-Verbindung);
Phenethyl isothiocyanate
2257-09-2

Phenethyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N-carbamimidoyl-N'-phenethyl-thiourea
46463-06-3

N-carbamimidoyl-N'-phenethyl-thiourea

Conditions
ConditionsYield
With sodium; acetone
p-acetoxyphenyl isothiocyanate
4061-59-0

p-acetoxyphenyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N-(4-acetoxy-phenyl)-N'-carbamimidoyl-thiourea
123790-75-0

N-(4-acetoxy-phenyl)-N'-carbamimidoyl-thiourea

Conditions
ConditionsYield
With sodium; acetone
propyl 4-nitrobenzoate
94-22-4

propyl 4-nitrobenzoate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

(4-nitro-benzoyl)-guanidine
3166-02-7

(4-nitro-benzoyl)-guanidine

Conditions
ConditionsYield
With sodium ethanolate
1 ,4-phenylenediisothiocyanate
4044-65-9

1 ,4-phenylenediisothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N',N'''-dicarbamimidoyl-N,N''-p-phenylene-bis-thiourea

N',N'''-dicarbamimidoyl-N,N''-p-phenylene-bis-thiourea

Conditions
ConditionsYield
With sodium; acetone
ethanol
64-17-5

ethanol

Khellin
82-02-0

Khellin

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

sodium ethanolate
141-52-6

sodium ethanolate

5-(2-amino-6-methyl-pyrimidin-4-yl)-4,7-dimethoxy-benzofuran-6-ol
52928-07-1

5-(2-amino-6-methyl-pyrimidin-4-yl)-4,7-dimethoxy-benzofuran-6-ol

Khellin
82-02-0

Khellin

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

5-(2-amino-6-methyl-pyrimidin-4-yl)-4,7-dimethoxy-benzofuran-6-ol
52928-07-1

5-(2-amino-6-methyl-pyrimidin-4-yl)-4,7-dimethoxy-benzofuran-6-ol

Conditions
ConditionsYield
With ethanol; sodium ethanolate
(3,4,5-trimethoxyphenyl)isothiocyanate
35967-24-9

(3,4,5-trimethoxyphenyl)isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N-carbamimidoyl-N'-(3,4,5-trimethoxy-phenyl)-thiourea

N-carbamimidoyl-N'-(3,4,5-trimethoxy-phenyl)-thiourea

Conditions
ConditionsYield
With sodium; acetone
4-hydroxyphenyl isothiocyanate
2131-60-4

4-hydroxyphenyl isothiocyanate

guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N-carbamimidoyl-N'-(4-hydroxy-phenyl)-thiourea

N-carbamimidoyl-N'-(4-hydroxy-phenyl)-thiourea

Conditions
ConditionsYield
With sodium; acetone
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

sodium ethanolate
141-52-6

sodium ethanolate

A

N-carbamimidoyl-N'-isopentyl-thiourea

N-carbamimidoyl-N'-isopentyl-thiourea

B

N,N'-bis-(isopentyl-thiocarbamoyl)-guanidine

N,N'-bis-(isopentyl-thiocarbamoyl)-guanidine

Conditions
ConditionsYield
With ethanol durch anschliessendes Kochen mit Isopentyl-isothiocyanat;
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

nitroguanidine
556-88-7

nitroguanidine

Conditions
ConditionsYield
With sulfuric acid; nitric acid
With sulfuric acid; nitric acid
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

1-phenyl-3-guanylthiourea
15989-47-6

1-phenyl-3-guanylthiourea

Conditions
ConditionsYield
With potassium hydroxide und anschliessend mit Phenylisothiocyanat;
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

1-p-chlorophenyl-3-formamidinothiocarbamide
7464-17-7

1-p-chlorophenyl-3-formamidinothiocarbamide

Conditions
ConditionsYield
With sodium; acetone anschliessend mit 4-Chlor-phenylisothiocyanat;
guanidinium thiocyanate
593-84-0

guanidinium thiocyanate

N-(4-bromo-phenyl)-N'-carbamimidoyl-thiourea
34678-12-1

N-(4-bromo-phenyl)-N'-carbamimidoyl-thiourea

Conditions
ConditionsYield
With sodium; acetone und anschliessend mit 4-Brom-phenylisothiocyanat;
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