N-Tosylimidates in highly enantioselective organocatalytic Michael reactions

Article abstract of DOI:10.1016/j.tetlet.2008.10.126

N-Tosylimidates acted as nucleophiles in highly enantioselective organocatalytic Michael addition reactions to α,β-unsaturated aldehydes in the presence of a catalytic amount of trialkylsilyl-protected diarylprolinol. In particular, α-phenyl-substituted N

Full text of DOI:10.1016/j.tetlet.2008.10.126

Tetrahedron Letters 50 (2009) 145–147
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Tetrahedron Letters
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N-Tosylimidates in highly enantioselective organocatalytic Michael reactions
*
Antonio Massa, Naoto Utsumi, Carlos F. Barbas III
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute,
10550 North Torrey Pines Road, La Jolla, CA 92037, United States
a r t i c l e i n f o
a b s t r a c t
Article history:
N-Tosylimidates acted as nucleophiles in highly enantioselective organocatalytic Michael addition
Received 19 September 2008
Revised 18 October 2008
Accepted 24 October 2008
Available online 31 October 2008
reactions to
diarylprolinol. In particular,
demonstrate that the kinetic acidity of the
proton/deuterium NMR exchange experiments is correlated with the potential of N-tosylimidates to
act as nucleophiles in organocatalytic reactions.
a
,b-unsaturated aldehydes in the presence of a catalytic amount of trialkylsilyl-protected
-phenyl-substituted N-tosylimidates showed good reactivity. We also
-proton of -phenyl N-tosylimidate as measured by
a
a
a
Ó 2008 Elsevier Ltd. All rights reserved.
The design and the use of new nucleophiles is an important
challenge that must be addressed in order to expand the scope of
direct organocatalytic reactions.1 Typically, the in situ generation
of effective nucleophiles based on reversible deprotonation and
amine catalysts under mild organocatalytic reaction conditions
requires pKa tuning since the proton to be abstracted must be
removed by a relatively weak amine base.2 For reactions using
primary and secondary amine catalysts, the pKa barrier for nucleo-
phile activation lies between the pKa values of 16 and 17. Simple
esters, with a pKa of about 19, are inert in these organocatalytic
reactions, whereas activated esters, like diethyl malonate with a
pKa of 16.4, are widely used.3
thioester (t1/2 ꢀ 230 min). These results suggest that N-sulfonyl-
imidate 1a should be an effective nucleophile under the iminium-
based Michael reaction conditions previously that were used for
trifluoroethyl thioesters.
We then tested the reactivity of N-tosylimidate 1a in a model
organocatalytic Michael addition to cinnamaldehyde in the pres-
ence of catalytic amount of racemic trialkylsilyl-protected diaryl-
prolinol 3 and benzoic acid co-catalyst in a variety of reaction
conditions (Scheme 1, Table 1). In this catalyst combination, diaryl-
prolinol 3 performs dual roles as both the base and the iminium
catalyst, whereas the benzoic acid acts as a catalyst of iminium for-
mation.2a In the polar protic solvent methanol, the desired product
was obtained after 16 h at room temperature with quantitative
conversion and in 86% isolated yield (mixture of 4a diastereomers)
(Table 1, entries 1 and 2). Significant solvent effects were noted,
Our recent studies demonstrated that simple trifluoroethyl thi-
oesters were effective in enantioselective organocatalytic Michael
addition reactions to
of trialkylsilyl-protected diarylprolinol.2 In the course of these
analyses, we evaluated the kinetic acidity of the -proton of a ser-
a,b-unsaturated aldehydes in the presence
a
ies of thioesters in proton/deuterium NMR exchange experiments.
This led us to propose that this method could be used to determine
the potential of molecules to act as nucleophiles in organocatalytic
reactions.
Imidates, also known as imidoates, imidic acid esters, or imido
esters, are important pharmacophores and useful synthetic build-
ing blocks.4 Recent analyses of the transformations of imidates
have increased interest in these molecules as functional groups.5
In order to investigate the potential of imidates in enantioselective
organocatalytic Michael addition reactions, we first evaluated the
1.0
HH
HD
DD
0.9
0.8
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0.0
kinetic acidity of the a-proton of N-sulfonylimidate 1a.
The results, shown in Figure 1, revealed a very rapid exchange
with a t1/2 of less than 10 min,6 comparable to that determined
0
30
60
90
120
for
a
-nitrophenyl trifluoroethyl thioester (t1/2 < 5 min) and signifi-
-phenyl trifluoroethyl
time (min)
cantly faster than that of the unsubstituted
a
Figure 1. Proton/deuterium exchange experiment of 1a: proton deuterium NMR
exchange experiments performed in the presence of CD3OD and catalytic quantity
* Corresponding author. Tel.: +1 858 784 9098; fax: +1 858 784 2583.
E-mail address: carlos@scripps.edu (C. F. Barbas III).
of Oct3N were used to determine the rate of exchange of the a-proton of N-
sulfonylimidate 1a.
0040-4039/$ - see front matter Ó 2008 Elsevier Ltd. All rights reserved.
doi:10.1016/j.tetlet.2008.10.126

146
A. Massa et al. / Tetrahedron Letters 50 (2009) 145–147
Ar
Ar
Ts
O
N
Ph
N
H
OTMS
Ph
O
H
Ph
H
+
(3: 0.1 eq)
Ph
Ph
benzoic acid, MeOH, 16 h
N
Ph
4a
O
O
Ts
Ar=3,5-bis(trifluoromethyl)phenyl
2a
1a
Scheme 1.
only the minor diastereomer in a 44% yield. The reaction, however,
was highly enantioselective, and the isolated product was obtained
with 98% ee (Table 2, entry 1). The by-product 5a was isolated in
26% yield, suggesting that the major diastereomer may decompose
during chromatography. Analysis of the mixed syn/anti products
prior to chromatography indicated that the major diastereomer
was also formed with high ee (Table 2, entry 2).
Table 1
Yields of organocatalytic Michael addition of 1a to cinnamaldehyde 2a using racemic
catalyst 3 under various conditions
Entry
Solvent
Time (h)
Conversiona (%)
Yieldb
dra
1
2
3
4
5
6
MeOH
MeOH
DMF
6
45
30
86
28
n.d.
n.d.
n.d.
56/44
55/45
57/43
55/45
n.d.
16
16
16
16
16
Quantitative
40
20
<10
<10
Et2O
Hexanec
Toluene
Ph
n.d.
Ph
O
H
a
Determined for crude reaction mixture by 1H NMR.
Yields refer to the mixture of diastereomers.
Compound 1a was not very soluble in hexane.
b
C
O
Ph
O
5a
and the conversion decreased rapidly with decreasing polarity of
the solvent used (Table 1, entries 3–6).
To optimize the reaction conditions, we studied the enantiose-
lectivity of the process using enantiopure, protected diarylprolinol
3 (Scheme 2, Table 2). Our attempts to separate the two diastereo-
mers of 4a by chromatography failed, and we were able to isolate
With the methyl N-sulfonylimidate 1b, we observed a good
conversion; again the major diastereomer of 4b was unstable to
chromatography. The minor diastereomer was readily isolated
with high ee (Table 2, entry 3). The imidate 1c, with a strong elec-
tron-withdrawing group in para position, showed a good reactivity,
Ar
SO2R2
Ar
R3
N
N
H
OTMS
R1
O
H
R
H
R3
+
(3: 0.1 eq)
R1
O
benzoic acid, MeOH, 16 h
N
R
O
O
R2O2S
Ar=3,5-bis(trifluoromethyl)phenyl
4
2
1
Scheme 2.
Table 2
Organocatalyzed Michael addition of imidates 1 to
a
,b-unsaturated aldehydes 2
Entry
Aldehyde (R)
R1
R2
R3
Conversion (%)a
Yield (%)
dra
eeb (%)
1
2
3
4
5
6
7
8
2a Ph
2a Ph
2a Ph
2a Ph
2a Ph
2a Ph
2a Ph
2a Ph
2b CH3
2c H
1a Ph
1a Ph
1b H
4-CH3C6H4
4-CH3C6H4
4-CH3C6H4
4-CH3C6H4
4-CH3C6H4
4-CH3C6H4
4-CH3C6H4
CH3
Ph
Ph
Ph
Quantitative
Quantitative
80
4a 44c
4a 85e
4b 38c
4c 87e
4d 50e
4e 50e
—
55/45
55/45
55/45
60/40
57/43
57/43
—
57/43
58/42
—
98d
97/98f
93d
1c Ph
1d Ph
1e Ph
1f Ph
1g Ph
1a Ph
1a Ph
1a Ph
4-CF3C6H4
4-CH3C6H4
4-CH3OC6H4
CH3OCH2
Ph
Ph
Ph
Ph
Quantitative
87/94f
60
50
0
50
70
0
95/94f
g
—
—
n.d.g
n.d.
52/45
—
9h
10
11h
4-CH3C6H4
4-CH3C6H4
4-CH3C6H4
4f 38/28i
—
n.d.
2c H
10
n.d.
n.d.
a
Determined for crude product by 1H NMR.
Determined by chiral-phase HPLC.
Isolated yield of the minor diastereomer. The major diastereomer decomposed during chromatography.
The ee of minor diastereomer.
Yields refer to the isolated mixture of diastereomers.
The ee was determined prior to chromatography.
The mixture of diastereomers was not stable.
b
c
d
e
f
g
h
i
Reaction solvent was DMF.
Isolated yields of major and minor diastereomers, respectively.

A. Massa et al. / Tetrahedron Letters 50 (2009) 145–147
147
Chem., Int. Ed. 2004, 43, 5138; (f) Notz, W.; Tanaka, F.; Barbas, C. F., III. Acc. Chem.
Res. 2004, 37, 580. and accompanying articles in this special issue on
organocatalysis.
which was comparable to that of 1a (entry 4). The imidates 1d and
1e were less reactive, presumably due to an electronic effect of
their para electron-releasing methyl and methoxy groups, respec-
2. (a) Alonso, D. A.; Kitagaki, S.; Utsumi, N.; Barbas, C. F., III. Angew. Chem., Int. Ed.
2008, 47, 4588; (b) Utsumi, N.; Kitagaki, S.; Barbas, C. F., III. Org. Lett. 2008, 10,
3405.
tively, that decreased the acidity of the
a proton (entries 5 and
6). Low stability of the major diastereomer was a common feature
for the imidates studied (entries 4–6). Product 4e was unusually
unstable and decomposed within in a few hours after purification
(entry 6). Imidate 1f was completely non-reactive, and at the end
of the standard reaction time it was quantitatively recovered (en-
try 7). The lower reactivity of 1f may be due to the absence of an
3. Selected studies on organocatalytic Micheal reactions: (a) Hayashi, Y.; Gotoh, H.;
Hayashi, T.; Shoji, M. Angew. Chem. 2005, 117, 4284. Angew. Chem., Int. Ed. 2005,
44, 4212; (b) Gotoh, H.; Masui, R.; Ogino, H.; Shoji, M.; Hayashi, Y. Angew. Chem.
2006, 118, 7007; (c) Hayashi, Y.; Okano, T.; Aratake, S.; Hazelard, D. Angew.
Chem. 2007, 119, 5010. Angew. Chem., Int. Ed. 2007, 46, 4922; (d) Gotoh, H.;
Hayashi, Y. Org. Lett. 2007, 9, 2859; (e) Marigo, M.; Wabnitz, T. C.; Fielenbach, D.;
Jørgensen, K. A. Angew. Chem. 2005, 117, 804. Angew. Chem., Int. Ed. 2005, 44,
794; (f) Marigo, M.; Fielenbach, D.; Braunton, A.; Kjaersgaard, A.; Jørgensen, K. A.
Angew. Chem. 2005, 117, 3769. Angew. Chem., Int. Ed. 2005, 44, 3703; (g)
Betancort, J. M.; Barbas, C. F., III. Org. Lett. 2001, 3, 3737; (h) Bui, T.; Barbas, C. F.,
III. Tetrahedron Lett. 2000, 41, 6951; (i) Alemán, J.; Cabrera, S.; Maerten, E.;
Overgaard, J.; Jørgensen, K. A. Angew. Chem. 2007, 119, 5616. Angew. Chem., Int.
Ed. 2007, 46, 5520; (j) Brandau, S.; Landa, A.; Franzen, J.; Marigo, M.; Jørgensen,
K. A. Angew. Chem. 2006, 118, 4411. Angew. Chem., Int. Ed. 2006, 45, 4305; (k)
Wang, J.; Li, H.; Zu, L.; Jiang, W.; Xie, H.; Duan, W.; Wang, W. J. Am. Chem. Soc.
2006, 128, 12652; (l) Shaolin, Z.; Shouyun, Y.; Dawei, M. Angew. Chem., Int. Ed.
2008, 47, 545; (m) Tan, B.; Chua, P. J.; Li, Y.; Zhong, G. Org. Lett. 2008, 10, 2437;
(n) Zhu, D.; Lu, M.; Chua, P. J.; Tan, B.; Wang, F.; Yang, X.; Zhong, G. Org. Lett.
2008. ASAP. For a review, see: (o) Palomo, C.; Mielgo, A. Angew. Chem. 2006, 118,
8042. Angew. Chem., Int. Ed. 2006, 45, 7876.
aromatic group in the
a position; this group may be needed to con-
fer sufficient acidity to the imidate under these mild conditions.
The methyl imine imidate was relatively non-reactive and the
products formed were unstable (entry 8).
Modification of the Michael acceptor substrate to crotonalde-
hyde 2b resulted in a stable product 4f. We were able to resolve
the two diastereomers by chromatography and analyze them inde-
pendently. Unfortunately, as was the case for our previous studies
using this Michael acceptor with trifluoroethyl thioester nucleo-
philes, the enantioselectivity was only moderate (entry 9). The in-
creased stability of 4f might be due to decreased steric hindrance
relative to the bisaromatic products. Acrolein 2c was not reactive
as a Michael acceptor. In reactions performed in methanol and
DMF, we recovered unreacted imidate 1a almost quantitatively
(entries 10 and 11).
4. (a) Yoo, E. J.; Ahlquist, M.; Bae, I.; Sharpless, K. B.; Fokin, V. V.; Chang, S. J. Org.
Chem. 2008, 73, 5520; (b) Yoo, E. J.; Bae, I.; Cho, S. H.; Han, H.; Chang, S. Org. Lett.
2006, 8, 1347.
5. (a) Matsubara, R.; Berthiol, F.; Kobayashi, S. J. Am. Chem. Soc. 2008, 130, 1804; (b)
Matsubara, R.; Kobayashi, S. Synthesis 2008, Advanced online publication.
6. t1/2 is approximated as the time at which the ratio of the imidate 1a and
a
-mono-deuterated derivative of 1a is 1.
General procedure for the Michael addition of imidates to
aldehydes: To solution of (S)- -bis[3,5-bis(trifluoromethyl)phenyl]-2-
pyrrolidinemethanol trimethylsilyl ether (3) (10 mol %, 0.015 mmol) and
benzoic acid (10 mol %, 0.015 mmol) in MeOH (0.20 mL) was added ,b-
In conclusion, we have developed a highly enantioselective
organocatalytic Michael addition of N-tosylimidates to a,b-unsatu-
rated aldehydes in the presence of catalytic amounts of trialkyl-
silyl-protected diarylprolinol. Significantly, the evaluation of the
a
,b -unsaturated
a
a,a
a
unsaturated aldehyde (1.3 equiv, 0.195 mmol). After the resulting mixture was
stirred at room temperature for 15 min, a previously prepared (2–3 min before
addition) MeOH (0.15 mL) solution of the imidate (0.15 mmol) was added
dropwise, and the reaction mixture was stirred for 16 h (until the imidate
disappeared as indicated by TLC). MeOH was then evaporated, and the
conversion and the diastereomeric ratio (dr) was determined by 1H NMR of
the crude product. The crude mixture was purified by flash chromatography
(hexane/EtOAc mixtures) to afford Michael adducts. The enantiomeric purity
was determined by chiral-phase HPLC analysis of the products.
kinetic acidity of the
ton/deuterium NMR exchange experiments indicated that rapid
rates of -proton exchange determined using this method are
a-proton of a-phenyl N-tosylimidate in pro-
a
indicative of reactivity as a nucleophile in aminocatalytic reactions.
Acknowledgments
Minor diastereomer (4a): viscous oil, 1H NMR (400 MHz, CDCl3): d 2.39 (s, 3H,
CH3), 2.45 (ddd, J = 17.2, 4.0, 1.2 Hz, 1H, ½ CH2CHO), 2.70 (ddd, J = 17.2, 10.4,
This study was supported by the Skaggs Institute for Chemical
Biology. Dr. Antonio Massa thanks the Fulbright Foundation for
support.
2.0 Hz, 1H,
½ CH2CHO), 4.00 (td, J = 11.0, 4.0 Hz, 1H, CHCHCH2), 4.68 (d,
J = 12.0 Hz, 1H, ½PhCH2O), 4.87 (d, J = 12.0 Hz, 1H, ½PhCH2O), 5.44 (d,
J = 11.0 Hz, 1H, CHC@N), 7.09 (d, J = 7.2 Hz, 2H, ArH), 7.17 (d, J = 8.0 Hz, 2H,
ArH), 7.19–7.35 (m, 11H, ArH), 7.53 (d, J = 8.0 Hz, 2H, ArH), 7.63 (d, J = 6.8 Hz, 2H,
ArH), 9.36 (br s, 1H, CHO). 13C NMR (100 MHz, CDCl3) d: 21.5, 43.3, 48.3, 53.6,
70.7, 126.5, 127.3, 128.2, 128.4, 128.5, 128.6, 128.7, 128.8, 129.1, 129.2, 129.4,
134.2, 135.8, 138.5, 140.6, 143.1, 171.7, 200.2. HRMS: calcd for C31H29NO4S
(MH+) 512.1890, found 512.1896. The ee was determined by chiral HPLC
analysis (Daicel Chiralcel OD-H, hexane/i-PrOH = 90/10, flow rate 1.0 mL/min,
k = 254 nm): tR (minor enantiomer) = 26.3 min, tR (major enantiomer) =
References and notes
1. (a) Dondoni, A.; Massi, A. Angew. Chem., Int. Ed. 2008, 47, 4638; (b) Barbas, C. F.,
III. Angew. Chem., Int. Ed. 2008, 47, 42; (c) Dalko, P. I., Ed. Enantioselective
Organocatalysis Reactions and Experimental Procedures; Wiley-VCH:
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107, 5416; (e) Dalko, P. I.; Moisan, L. Angew. Chem. 2004, 116, 5248. Angew.
35.3 min. ½a 2D5
ꢂ 29:0 (c 1.0, CHCl3, 98% ee).
ꢁ