Synthesis p. 418 - 420 (1987)
Update date:2022-09-26
Topics:
Nakonieczna, Lucja
Chimiak, Andrzej
The concept of transient hydroxylamine oxygen protection for the unambiguous synthesis of N-hydroxyamides has been applied in the amino acid field.First, hydroxylamines 1 were silylated in pyridine with chlorotrimethylsilane; then 2 was immediately N-acylated with mixed anhydride 3 of a protected amino acid or peptide; and finally, the O-trimethylsilyl protection was removed during the isolation procedure giving pure N-hydroxyamides 5.
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Doi:10.1016/S0040-4039(00)96090-8
(1987)Doi:10.1016/S0040-4039(00)83868-X
(1986)Doi:10.1021/jm9014857
(2010)Doi:10.1016/j.tet.2009.01.013
(2009)Doi:10.1055/s-0028-1087672
(2009)Doi:10.1002/chem.202101459
(2021)
