Indolylarylsulfones bearing natural and unnatural amino acids. discovery of potent inhibitors of hiv-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie b4 virus

DOI: 10.1021/jm801470b

Source and publish data:

Journal of Medicinal Chemistry p. 1922 - 1934 (2009)

Update date:2022-09-26

Topics:

Authors:

Piscitelli, Francesco

Coluccia, Antonio

Brancale, Andrea

La Regina, Giuseppe

Sansone, Anna

Giordano, Cesare

Balzarini, Jan

Maga, Giovanni

Zanoli, Samantha

Samuele, Alberta

Cirilli, Roberto

La Torre, Francesco

Lavecchia, Antonio

Novellino, Ettore

Silvestri, Romano

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Article abstract of DOI:10.1021/jm801470b

New potent indolylarylsulfone (IAS) HIV-1 NNRTIs were obtained by coupling natural and unnatural amino acids to the 2-carboxamide and introducing different electron-withdrawing substituents at position 4 and 5 of the indole nucleus. The new IASs inhibited

Full text of DOI:10.1021/jm801470b

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