1988-11-0

Usage

InChI:InChI=1/C12H16O2/c1-7(2)10-5-9(13)6-11(8(3)4)12(10)14/h5-8H,1-4H3

Upstream product

• 26378-36-9 2-tert-butyl-3-(4-nitrophenyl)-1,2-oxaziridine 
• 2078-54-8 2,6-diisopropylphenol 
• 75-30-9 2-iodo-propane 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 106-51-4 p-benzoquinone 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 2178-51-0 3,3',5,5'-tetraisopropyldiphenoquinone 
• 99-96-7 4-hydroxy-benzoic acid 
• 13423-73-9 4-hydroxy-3,5-diisopropylbenzoic acid 
• 78-84-2 isobutyraldehyde 
• 79-31-2 isobutyric Acid 

Downstream Products

• 83638-48-6 4-hydroxy-2,6-di-isopropyl-4-phenylcyclohexa-2,5-dienone 
• 83638-50-0 4-hydroxy-3,5-di-isopropyl-4-phenylcyclohexa-2,5-dienone 
• 153475-03-7 3,5-diisopropyl-2-methylbenzene-1,4-diol 
• 857975-06-5 2,6-diisopropyl-3,5-dimethylbenzene-1,4-diol 
• 1988-10-9 2,6-di(2-propyl)hydroquinone 
• 89049-42-3 7-(2,6-dichlorophenyl)-1,3-diisopropyl-8-aza-9-oxa-<4.3.0>bicyclonona-3,7-diene-2,5-dione 
• 125923-13-9 4-[2-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-4-hydroxy-2,6-diisopropyl-cyclohexa-2,5-dienone 
• 83638-51-1 4-cyano-2,6-di-isopropyl-4-trimethylsiloxycyclohexa-2,5-dienone 

Relevant academic research and scientific papers

Synthesis and characterization of titanium-containing mesoporous silica by a non-hydrothermal microwave method

We report on a new method for preparing mesoporous silica and titanium-containing mesoporous silica using microwave (MW) synthesis under non-hydrothermal conditions. The materials were characterized by XRD, nitrogen adsorption, UV-vis and FTIR techniques, and compared with a sample prepared by the conventional method. A single peak at 2θ = 2.4°in the XRD pattern showed the formation of mesoporous silica. A typical isotherm, characteristic of a mesoporous material where pore filling occurred at p/p0 in the range of 0.2 - 0.3 was obtained for nitrogen sorption. UV-vis diffused reflectance spectra showed bands at 210 - 220 nm and a shoulder at 270 nm, indicating the presence of Si-O-Ti bonds for titanium-containing mesoporous silica. This new method has been observed to have inherent advantages over reported methods, such as instant start up, a short heating time and low cost. These mesoporous titanosilicates prepared using a microwave heat energy source are active in the oxidation of 2,6-diisopropylphenol (DIPP) and 2,6-di-t-butylphenol (DTBP) with hydrogen peroxide as an oxidant.

A green mesostructured vanadosilicate catalyst and its unprecedented catalytic activity for the selective synthesis of 2,6-disubstituted p-benzoquinones

We have developed a green method for the production of 2,6-disubstituted p-benzoquinones (DSBQs) by liquid-phase oxidations of di/tri-substituted phenols using two-dimensional hexagonally thick-walled mesoporous vanadosilicate catalysts. In particular, 2,6-di-tert-butyl-p-benzoquinone was synthesized by the oxidation of 2,6-di-tert-butylphenol, using various reaction parameters, over mesoporous VSBA-15 catalysts synthesized with various vanadium contents. A promising chemical treatment method for the preparation of green mesoporous VSBA-15(5) or W-VSBA-15(5) (W: washed) catalysts was successfully used in the presence of ammonium acetate solution to remove moderately toxic non-framework V2O5 crystallite species from the active surface, and the catalytic activity of the recovered green mesoporous VSBA-15(5) catalyst was determined. To confirm the green aspects, recyclability and hot-catalytic filtration experiments were performed. The combined results show that the green mesoporous VSBA-15(5) is a highly active, recyclable, and promising heterogeneous catalyst for the selective synthesis of DSBQs (98-100%), and has unprecedented catalytic activity compared with other mesoporous vanadosilicate catalysts. The Royal Society of Chemistry 2014.

Oxidative coupling of some 2,6-disubstituted phenol derivatives in perchloric acid mediated by cerium(IV) ions

2,6-Disubstituted phenol derivatives have been oxidized by cerium(IV) perchlorate in aqueous or aqueous-acetonitrile solutions of perchloric acid as well as in two-phase systems to the corresponding 1,4-benzoquinones, 4,4′-diphenoquinones, and oligomeric

Oxidation of 4,4'-diphenoquinones giving p-benzoquinones

4,4'-Diphenoquinone 1a can be oxygenated to give p-benzoquinone 2a when treated with PbO2 in a solvent containing an aqueous acid. The conversion of 1a is facilitated when the acid is strong and the solvent is of low basicity. The concentration of H2O in the medium also has a profound effect on the rate of conversion of 1a. These facts may indicate that protonation of 1a is the first step in the conversion into 2a. 4,4'-Diphenoquinones 1b and 1c can be analogously converted into p-benzoquinones 2a and 2b, respectively. Benzoquinones 2 can thus be the ultimate products of both oxygenation and dehydrogenative dimerization of phenols 3. (C) 2000 Elsevier Science Ltd.

Selective synthesis of benzoquinones over Cu(ii)-containing propylsalicylaldimine functionalized mesoporous solid catalysts

The major product, 2,3,5-trimethyl-1,4-benzophenone (TMBO), was synthesised by an eco-friendly liquid-phase oxidation of 2,3,6-trimethylphenol (TMP-OH) over Cu(ii)-containing propylsalicylaldimine (CSA) functionalized mesoporous solid catalysts, namely, CSASBA-15(0.2), CSASBA-15(0.1) and CSAMCM-41(0.2), synthesized using various amounts of copper in a simple post-grafting method using different mesoporous silica materials, e.g., thick-silica walled SBA-15 and thin-silica walled MCM-41. The benzoquinones, i.e., 2,6-disubstituted p-benzoquinones (DSBQs), were also synthesised by the slurry-phase oxidation of di/tri-substituted phenols using the prepared catalysts. A promising chemical treatment was used for the removal of extra-framework copper species from the active surface of CSASBA-15(0.2), and the catalytic activity of the recovered catalyst, i.e. green mesoporous CSASBA-15(0.2) or W-CSASBA-15(0.2), was evaluated. Various reaction parameters, oxidants and solvents were used in this catalytic oxidation. To confirm the catalytic stability, recyclability and hot-catalytic filtration experiments were performed. On the basis of all catalytic results, it is worth noting that the mesoporous CSASBA-15(0.2) is an outstanding and a promising heterogeneous catalyst for the selective synthesis of TMBO and DSBQs, and produces 98% TMBO selectivity with 100% TMP-OH conversion at 353 K for 40 min and 97-99% DSBQ selectivity with 98-100% di/tri-substituted phenols conversion at 330 K for 1-3 h. The green mesoporous catalyst has unprecedented catalytic activity compared with that of other CSA functionalized mesoporous solid catalysts.

Indirect evidence for a NiIII-oxyl oxidant in the reaction of a NiII complex with peracid

The reaction of a NiII complex and meta-chloroperoxybenzoic acid (m-CPBA) resulted in the formation of a long-lived NiIII-chlorobenzoate complex that is a capable hydrocarbon oxidant. Analysis of the post-reaction decay products showed the formation of oxidised derivatives of the supporting ligand (a benzoxazine), and heterolytic O-O bond scission in m-CPBA. This evidence indicates formation of a more potent transient NiIII-oxyl species, which was further supported by DFT calculations.

Selective activation of C–H bond into C[dbnd]O bond of phenols in para-position via aerobic oxidation

An efficient method for the oxidation of phenols to 1,4-benzoquinones catalyzed by cuprous(I) chloride was achieved in a solution of acetonitrile and water using molecular dioxygen as an oxidant. Particularly, the inert phenols, such as phenol and mono-alkyl substituted phenols, were effectively oxidized to 1,4-benzoquinones via the selective activation of C–H bond in para-position into C[dbnd]O bond under mild conditions. The catalyst shows high activity for unsubstituted or alkyl substituted phenols, but no effect on substituted phenols with electron-withdrawing groups. This study offers an aerobic method for the selective oxidation of aromatic phenols to 1,4-benzoquinones.

Quinone C-H Alkylations via Oxidative Radical Processes

A brief survey of radical additions to quinones is reported. Carboxylic acids, aldehydes, and unprotected amino acids are compared as alkyl radical precursors for the mono- or bis- C-H alkylation of several quinones. Two methods for radical initiation are discussed comparing inorganic persulfates and Selectfluor as stoichiometric oxidants. Kinetic analysis reveals dramatic differences in the rate of radical initiation depending on the identity of the radical precursor and oxidant. Synthetic strategies for efficiently producing alkyl-quinones are discussed in the context of selecting optimum radical precursors and initiators depending on quinone identity and functional groups present.

COMPOUND FOR THE PROPHYLAXIS OR TREATMENT OF ORGAN DAMAGE

The present invention relates to compounds for prophylaxis or treatment of organ damage by restoring endothelial function and/or inhibiting reactive oxygen species production and especially to compounds for prophylaxis or treatment of diabetic kidney dama

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-COMPOUNDS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE AIRWAY DISEASES

The present invention relates to compounds for the treatment of chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD) or asthma or bronchiectasis. The present invention further relates to drug delivery devices suitable t