Increasing time on target: utilization of inhibitors of cysteine cathepsins to enhance the tumor retention of receptor-targeted agents

DOI: 10.1039/c8cc05982a

Source and publish data:

Chemical Communications p. 11268 - 11271 (2018)

Update date:2022-08-04

Topics:

Authors:

Fan, Wei

Zhang, Wenting

Alshehri, Sameer

Garrison, Jered C.

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Article abstract of DOI:10.1039/c8cc05982a

We report a strategy of utilizing irreversible cysteine cathepsin inhibitor as trapping agent to increase the tumor residence time of receptor-targeted agents. The targeted constructs incorporating these cysteine cathepsin trapping agents were able to for

Full text of DOI:10.1039/c8cc05982a

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