Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: Synthesis and antiviral activity

DOI: 10.1021/jm00117a026

Source and publish data:

Journal of Medicinal Chemistry p. 1831 - 1839 (1988)

Update date:2022-07-31

Topics:

Authors:

Griengl Griengl

Hayden Hayden

Penn Penn

De Clercq

Rosenwirth

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Article abstract of DOI:10.1021/jm00117a026

The synthesis of potential 'combined prodrugs' wherein phosphonoformate or phosphonoacetate was attached to the 5'-position of 2'-deoxyuridine, 2'-deoxythymidine, 5-iodo-2'-deoxyuridine (IDU), 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), or 5-(2-bromovinyl)-

Full text of DOI:10.1021/jm00117a026

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