Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: Synthesis and antiviral activity

DOI: 10.1021/jm00117a026

Source and publish data:

Journal of Medicinal Chemistry p. 1831 - 1839 (1988)

Update date:2022-07-31

Topics:

Authors:

Griengl Griengl

Hayden Hayden

Penn Penn

De Clercq

Rosenwirth

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00117a026

The synthesis of potential 'combined prodrugs' wherein phosphonoformate or phosphonoacetate was attached to the 5'-position of 2'-deoxyuridine, 2'-deoxythymidine, 5-iodo-2'-deoxyuridine (IDU), 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), or 5-(2-bromovinyl)-

Full text of DOI:10.1021/jm00117a026

Products guided by the article

Product name:5-(2-chloroethyl)-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Cas No:115365-33-8

R&D Labs maybe for 115365-33-8

Chongqing KonAo Health Co.,Ltd

Contact:13687578375

Address:wuhan hubei china
Changzhou Screw International Trading Co., Ltd.

Contact:13906149256,18001495888

Address:Jiangsu，Jintanqu
Taimai Sanluck Pharmaceutical Co.,Ltd

Contact:86-592-7662921

Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Naturalin Bio-Resource Co., Ltd

website:http://www.naturalin.com

Contact:+86-0731-84430651

Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Jiangsu Seed Chem Co.,Ltd.

Contact:86-513-84128750/13773795976

Address:No.48.Youyi West Road ,Rudong Development Zone,Jiangsu Province,China

Relevant to this article

REACTION OF 2,4,6-TRIPHENYLVERDAZYL WITH TRIFLUOROMETHYLSULFONYLCARBETHOXYDIBROMOMETHANE

Doi:10.1007/BF00479375
(1987)
Asymmetric synthesis of neolignans (-)-epi-Conocarpan and (+)-Conocarpan via Rh(II)-catalyzed C-H insertion process and revision of the absolute configuration of (-)-epi-Conocarpan

Doi:10.1021/jo900502d
(2009)
Smaller, faster, better: Modular synthesis of unsymmetrical ammonium salt-tagged NHC-gold(i) complexes and their application as recyclable catalysts in water

Doi:10.1039/c5ob01286d
(2015)
Mild Pd/Cu-catalyzed sila-sonogashira coupling of (hetero)aryl bromides with (hetero)arylethynylsilanes under PTC conditions

Doi:10.1055/s-0031-1290601
(2012)
SYNTHESIS AND STRUCTURE OF 2,6-DI-TERT-BUTYL-1,4-BENZOQUINONE-4N-(8-TOSYLAMINO-1-NAPHTHYL)IMINE

Doi:10.1007/BF01172258
(1991)
Palladium-catalyzed amidation by chemoselective C(sp³)-H activation: Concise route to oxindoles using a carbamoyl chloride precursor

Doi:10.1002/anie.201108889
(2012)

Article Doi