Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: Synthesis and antiviral activity

DOI: 10.1021/jm00117a026

Source and publish data:

Journal of Medicinal Chemistry p. 1831 - 1839 (1988)

Update date:2022-07-31

Topics:

Authors:

Griengl Griengl

Hayden Hayden

Penn Penn

De Clercq

Rosenwirth

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00117a026

The synthesis of potential 'combined prodrugs' wherein phosphonoformate or phosphonoacetate was attached to the 5'-position of 2'-deoxyuridine, 2'-deoxythymidine, 5-iodo-2'-deoxyuridine (IDU), 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), or 5-(2-bromovinyl)-

Full text of DOI:10.1021/jm00117a026

Products guided by the article

Product name:5-(2-chloroethyl)-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Cas No:115365-33-8

R&D Labs maybe for 115365-33-8

jintan yufan Medicine Raw materials Co.,Ltd.(expird)

Contact:86-519-82808282

Address:6th,Jincheng Huangzhuang
Hangzhou utanpharma Co., Ltd

Contact:86-571-87758773

Address:Room604 ,6F, Block A1-3 Xixi Plaza,No. 588 Wenyi West RD, Hangzhou,310012, China
Dalian Synco Chemical Co., Ltd.

Contact:+86-411-83635150

Address:Rm 1004, 24, Tangshan Street, Dalian
SHUNYUANSHENG BIO-PHARMTECH CO., LTD

website:https://www.whsysbio.com

Contact:--

Address:Building 13, Liandong U Valley-Wuhan Economic Innovation Valley, No. 259, Xingsan Road, Shamao Street, Hannan District, Wuhan City, Hubei Province
Shanghai Yingrui Biopharma Co., Ltd

Contact:021-3358 8661*8003

Address:shanghai

Relevant to this article

REACTION OF 2,4,6-TRIPHENYLVERDAZYL WITH TRIFLUOROMETHYLSULFONYLCARBETHOXYDIBROMOMETHANE

Doi:10.1007/BF00479375
(1987)
Asymmetric synthesis of neolignans (-)-epi-Conocarpan and (+)-Conocarpan via Rh(II)-catalyzed C-H insertion process and revision of the absolute configuration of (-)-epi-Conocarpan

Doi:10.1021/jo900502d
(2009)
Smaller, faster, better: Modular synthesis of unsymmetrical ammonium salt-tagged NHC-gold(i) complexes and their application as recyclable catalysts in water

Doi:10.1039/c5ob01286d
(2015)
Mild Pd/Cu-catalyzed sila-sonogashira coupling of (hetero)aryl bromides with (hetero)arylethynylsilanes under PTC conditions

Doi:10.1055/s-0031-1290601
(2012)
SYNTHESIS AND STRUCTURE OF 2,6-DI-TERT-BUTYL-1,4-BENZOQUINONE-4N-(8-TOSYLAMINO-1-NAPHTHYL)IMINE

Doi:10.1007/BF01172258
(1991)
Palladium-catalyzed amidation by chemoselective C(sp³)-H activation: Concise route to oxindoles using a carbamoyl chloride precursor

Doi:10.1002/anie.201108889
(2012)

Article Doi