2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

Article abstract of DOI:10.1016/j.bmcl.2008.02.026

The identification of class II HDAC inhibitors has been hampered by lack of efficient enzyme assays, in the preceding paper two assays have been developed to improve the efficiency of these enzymes: mutating an active site histidine to tyrosine, or by the