A Mechanistic Study of the Mitsunobu Esterification Reaction

DOI: 10.1021/ja00227a032

Source and publish data:

Journal of the American Chemical Society p. 6487 - 6491 (1988)

Update date:2022-09-26

Topics: Catalyst Esterification Nucleophilic substitution Mitsunobu reaction alcohol Carboxylic acid Experimental Setup Mechanistic study Phosphine

Authors:

Hughes, D. L.

Reamer, R. A.

Bergan, J. J.

Grabowski, E. J. J.

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Article abstract of DOI:10.1021/ja00227a032

The three steps of the Mitsunobu reaction were studied in detail for the esterification, with inversion of configuration, of the 2-(hydroxyethyl)azetidinone 1A.In all solvents examined, formation of the adduct between DIAD and PPh3 occurs far more rapidly

Full text of DOI:10.1021/ja00227a032

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