Journal of the American Chemical Society p. 6487 - 6491 (1988)
Update date:2022-09-26
Topics: Catalyst Esterification Nucleophilic substitution Mitsunobu reaction alcohol Carboxylic acid Experimental Setup Mechanistic study Phosphine
Hughes, D. L.
Reamer, R. A.
Bergan, J. J.
Grabowski, E. J. J.
The three steps of the Mitsunobu reaction were studied in detail for the esterification, with inversion of configuration, of the 2-(hydroxyethyl)azetidinone 1A.In all solvents examined, formation of the adduct between DIAD and PPh3 occurs far more rapidly
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Doi:10.1039/b820449g
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