Microbiological transformations 40. Use of fungal epoxide hydrolases for the synthesis of enantiopure alkyl epoxides

Article abstract of DOI:10.1016/S0040-4020(97)10394-5

The enantioselective biohydrolyses of various substituted alkyl-epoxides using seven different fungi are described. These strains were used to achieve the preparation of these alkyl epoxides in high enantiomeric purity. A combined chemoenzymatic process is also described, allowing to enhance the overall yield of such an approach.