Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy

DOI: 10.1016/j.bmc.2009.04.040

Source and publish data:

Bioorganic and Medicinal Chemistry p. 3800 - 3809 (2009)

Update date:2022-08-04

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Authors:

Iino, Tomoharu

Hashimoto, Noriaki

Sasaki, Kaori

Ohyama, Sumika

Yoshimoto, Riki

Hosaka, Hideka

Hasegawa, Takuro

Chiba, Masato

Nagata, Yasufumi

Eiki, Jun-ichi

Nishimura, Teruyuki

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Article abstract of DOI:10.1016/j.bmc.2009.04.040

The optimization of our lead GK activator 2a to 3-[(1S)-2-hydroxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide (6g), a potent GK activator with good oral availability, is described, including to uncouple the relationship betwe

Full text of DOI:10.1016/j.bmc.2009.04.040

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Product name:3-[(1R)-2-hydroxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]-N-1,3-thiazol-2-ylbenzamide

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