SYNTHESIS OF A POTENT ANTITHROMBIN ACTIVATING PENTASACCHARIDE: A NEW HEPARIN LIKE FRAGMENT CONTAINING TWO 3-O-SULPHATED GLUCOSAMINES

DOI: 10.1016/S0040-4039(00)80214-2

Source and publish data:

Tetrahedron Letters p. 803 - 806 (1988)

Update date:2022-07-30

Topics:

Authors:

Boeckel, C. A. A. van

Beetz, T.

Aelst, S. F. van

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Article abstract of DOI:10.1016/S0040-4039(00)80214-2

The synthesis of a pentasaccharide corresponding to the antithrombin III binding region of heparin, but containing an extra 3-O-sulphate group at the reducing end, is described.This compound elicits higher anti-Xa activity than the antithrombin III bindin

Full text of DOI:10.1016/S0040-4039(00)80214-2

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