SYNTHESIS OF A POTENT ANTITHROMBIN ACTIVATING PENTASACCHARIDE: A NEW HEPARIN LIKE FRAGMENT CONTAINING TWO 3-O-SULPHATED GLUCOSAMINES

Article abstract of DOI:10.1016/S0040-4039(00)80214-2

The synthesis of a pentasaccharide corresponding to the antithrombin III binding region of heparin, but containing an extra 3-O-sulphate group at the reducing end, is described.This compound elicits higher anti-Xa activity than the antithrombin III bindin