Bioorganic and Medicinal Chemistry Letters p. 3541 - 3545 (2009)
Update date:2022-08-04
Topics:
Tice, Colin M.
Xu, Zhenrong
Yuan, Jing
Simpson, Robert D.
Cacatian, Salvacion T.
Flaherty, Patrick T.
Zhao, Wei
Guo, Joan
Ishchenko, Alexey
Singh, Suresh B.
Wu, Zhongren
Scott, Boyd B.
Bukhtiyarov, Yuri
Berbaum, Jennifer
Mason, Jennifer
Panemangalore, Reshma
Cappiello, Maria Grazia
Mueller, Dominik
Harrison, Richard K.
McGeehan, Gerard M.
Dillard, Lawrence W.
Baldwin, John J.
Claremon, David A.
Structure-based drug design led to the identification of a novel class of potent, low MW alkylamine renin inhibitors. Oral administration of lead compound 21l, with MW of 508 and IC50 of 0.47 nM, caused a sustained reduction in mean arterial bl
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Doi:10.1021/ja904575e
(2009)Doi:10.1016/S0040-4039(00)80218-X
(1988)Doi:10.1016/j.tetlet.2009.05.094
(2009)Doi:10.1002/adsc.200900080
(2009)Doi:10.1016/j.ica.2021.120409
(2021)Doi:10.1055/s-0029-1217169
(2009)
