A STEREOSPECIFIC SYNTHESIS OF (4R)-4--4,N-DIMETHYL-L-THREONINE (MeBmt)

DOI: 10.1016/S0040-4039(00)87837-5

Source and publish data:

Tetrahedron Letters p. 2069 - 2072 (1988)

Update date:2022-08-04

Topics:

Authors:

Rao, A. V. Rama

Dhar, T. G. Murali

Chakraborty, T. K.

Gurjar, M. K.

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Article abstract of DOI:10.1016/S0040-4039(00)87837-5

The utility of readily obtainable cis-oxazolidinone derivative (14) has been explored for the efficient and stereospecific synthesis of (4R)-4-<(E)-2-butenyl>-4,N-dimethyl-L-threonine, an unusual syn-β-hydroxy-α-amino acid of cyclosporine.

Full text of DOI:10.1016/S0040-4039(00)87837-5

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