13269-47-1

Basic information

• Product Name: 1-Amino-3-buten-2-ol
• Synonyms: 1-Amino-3-buten-2-ol
• CAS NO: 13269-47-1
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.12036
• Mol File: 13269-47-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 33-37 °C
• Boiling Point: 174.6°Cat760mmHg
• Flash Point: 59.4°C
• Appearance: /
• Density: 0.955g/cm³
• Vapor Pressure: 0.371mmHg at 25°C
• Refractive Index: 1.467
• PKA: 12.11±0.35(Predicted)
• CAS DataBase Reference: 1-Amino-3-buten-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Amino-3-buten-2-ol(13269-47-1)
• EPA Substance Registry System: 1-Amino-3-buten-2-ol(13269-47-1)

Safety Data

• Hazardous Substances Data: 13269-47-1(Hazardous Substances Data)

Usage

General Description

1-Amino-3-buten-2-ol, also known as 2-Amino-1-butene-3-ol, is a chemical compound with the molecular formula C4H9NO. It is a primary amine and an alcohol, featuring a terminal double bond and an amino group. As a colorless liquid, it has a boiling point of 166-168°C and is soluble in water and ethanol. It is used in the manufacturing of pharmaceuticals and other organic compounds. The compound is also known to possess biological activity, such as being a reactive intermediate in the biosynthetic pathway of certain plant alkaloids. Additionally, 1-Amino-3-buten-2-ol is used in the synthesis of various chemicals and as a reagent in organic chemistry reactions.

InChI:InChI=1/C4H9NO/c1-2-4(6)3-5/h2,4,6H,1,3,5H2

Upstream product

• 1595205-41-6 (R)-2-(2-hydroxylbut-3-enyl)isoindoline-1,3-dione 
• 40326-19-0 2-<(trimethylsilyl)oxy>-3-butenenitrile 
• 134676-36-1 (2-Hydroxy-but-3-enyl)-carbamic acid tert-butyl ester 
• 930-22-3 epoxybutene 
• 7664-41-7 ammonia 
• 5809-59-6 3-cyano-3-hydroxy-1-propene 
• 1254120-10-9 1-azido-but-3-en-2-ol 
• 15667-63-7 2-acetoxy-3-butenenitrile 
• 89124-74-3 1-nitrobut-3-en-2-ol 
• 75-52-5 nitromethane 
• 107-02-8 acrolein 

Downstream Products

• 500-12-9 DL-5-vinyloxazolidine-2-thione (goitrin) 
• 1083074-03-6 C₁₇H₂₆N₂O₄ 
• 1072-93-1 (5R)-5-vinyl-1,3-oxazolidine-2-thione 
• 620622-24-4 N-(p-methoxyphenylamino)-3-buten-2-ol 

Relevant articles and documents

An improved synthesis of the antithyroid factor DL-goitrin

DL-1-Amino-3-buten-2-ol H2C=CH-CH(OH)-CH2NH2 has been synthesized in a satisfactory overall yield by reduction of the protected cyanohydrin H2C=CH-CH(OR)-CN with aluminum hydride, followed by removal of the protecting group with aqueous hydrochloric acid and treatment with potassium hydroxide.The amino alcohol is a key intermediate in a synthesis of the antithyroid goitrin reported previously.

Cobalt-Catalyzed Hydroalkynylation of Vinylaziridines

Transition metal-catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose the cobalt-catalyzed hydroalkynylation of vinylaziridines giving rise to both linea

Preparation method of 5-vinyl-2-sulfo-oxazolidine

The invention discloses a preparation method of 5-vinyl-2-sulfo-oxazolidine. The preparation method comprises the following steps: (1) using acrolein and trimethylsilyl cyanide as raw materials for reaction under the catalysis of zinc iodide to obtain 2-[(trimethyorganosilyl)oxy]-3-butenenitrile; (2) in a toluene solution, using a red aluminum solution as a reducing agent and potassium carbonate and methanol as a desiliconizing agent, performing reduction and desiliconization on the 2-[(trimethyorganosilyl)oxy]-3-butenenitrile to obtain 1-amino-3-butene-2-alcohol; (3) enabling the 1-amino-3-butene-2-alcohol to react with carbon disulfide, and using hydrogen peroxide as a desulfurizing agent to obtain the 5-vinyl-2-sulfo-oxazolidine. The fatty chain cyanogroup used in the preparation methodis the red aluminum solution; compared with conventional lithium aluminum hydride, the red aluminum solution has simple operation conditions and is low in cost. In the reduction, methylbenzene, instead of traditional combustible liquid such as diethyl ether and the like, is used as a solvent, so that the reaction conditions are safer. In the annulations in the step (3), the hydrogen peroxide replaces original lead nitrate and serves as the desulfurizing agent, so that the pollution to the environment can be reduced, and the method is safe and environmentally-friendly.

SHORT-ACTING BENZODIAZEPINE DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF

The present invention relates to a benzodiazepine derivative of Formula I as a short-acting anesthetic, a pharmaceutical composition comprising the same, a kit comprising the same, a preparation method thereof, an method of anesthesia using the same and use thereof in the manufacture of an anesthetic medicament.