Synthesis and hybridization of 2′-O-methyl-RNAs incorporating 2′-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair

DOI: 10.1016/j.bmc.2009.08.053

Source and publish data:

Bioorganic and Medicinal Chemistry p. 7275 - 7280 (2009)

Update date:2022-08-02

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Authors:

Seio, Kohji

Tawarada, Ryuya

Sasami, Takeshi

Serizawa, Masashi

Ise, Misako

Ohkubo, Akihiro

Sekine, Mitsuo

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Article abstract of DOI:10.1016/j.bmc.2009.08.053

2′-O-Carbamoyluridine (U_cm) was synthesized and incorporated into DNAs and 2′-O-Me-RNAs. The oligonucleotides incorporating U_cm formed less stable duplexes with their complementary and U_cm-U, U_cm-C single-base m

Full text of DOI:10.1016/j.bmc.2009.08.053

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