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1,3-Thiazolidin-4-one is a heterocyclic compound characterized by a five-membered ring containing sulfur and nitrogen atoms at positions 1 and 3, respectively, and a carbonyl group at position 4. It serves as a versatile scaffold in medicinal chemistry due to its broad spectrum of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Derivatives of 1,3-thiazolidin-4-one are often explored for their potential as enzyme inhibitors or therapeutic agents, owing to their ability to interact with various biological targets. The core structure is also amenable to structural modifications, enhancing its pharmacological relevance. Other names for 1,3-thiazolidin-4-one include 4-thiazolidinone and thiazolidin-4-one.

2281-74-5

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2281-74-5 Usage

Chemical structure

A heterocyclic organic compound containing a five-membered ring with sulfur, nitrogen, and oxygen atoms.

Synonyms

Thiazolidinone.

Reactivity

Versatile reactivity due to the presence of multiple heteroatoms in the ring.

Applications

Widely used in the synthesis of pharmaceuticals, agrochemicals, and materials.

Biological activities

Exhibits antimicrobial, antiviral, anti-inflammatory, and anticancer properties.

Drug discovery

Attractive targets for drug discovery and development due to their diverse biological activities.

Coordination chemistry

Utilized as ligands in coordination chemistry.

Building blocks

Used as building blocks for the construction of complex molecules.

Research and industry

An important and valuable chemical compound in various fields of research and industry.

Check Digit Verification of cas no

The CAS Registry Mumber 2281-74-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,8 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2281-74:
(6*2)+(5*2)+(4*8)+(3*1)+(2*7)+(1*4)=75
75 % 10 = 5
So 2281-74-5 is a valid CAS Registry Number.

2281-74-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-oxothiazolidine

1.2 Other means of identification

Product number -
Other names 4-oxo-thiazolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2281-74-5 SDS

2281-74-5Downstream Products

2281-74-5Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS

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Page/Page column 46, (2020/08/28)

The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebra

2-(n-cyanoimino)-thiazolidin-4-one derivatives

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, (2008/06/13)

A class of novenl compounds represented by the formula (I) STR1 wherein R1 s are the same or different groups and each represents hydrogen atom or alkyl group having 1 to 4 carbon atoms; R2 is phenyl group, naphthyl group, or either

Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6- fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5-trimethyl-4- thiazolidinone maleate

Hrib, Nicholas J.,Jurcak, John G.,Bregna, Deborah E.,Burgher, Kendra L.,Hartman, Harold B.,Kafka, Sharon,Kerman, Lisa L.,Kongsamut, Sam,Roehr, Joachim E.,Szewczak, Mark R.,Woods-Kettelberger, Ann T.,Corbett, Roy

, p. 4044 - 4057 (2007/10/03)

HP-236 (3-[4-[4-(6-Fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone maleate; P-9236) (54) displayed a pharmacological profile indicative of potential atypical antipsychotic activity. A series of piperazinyl butyl thiazolidi

Synthesis of 4-Thiazolidinones From Rhodanines by Thiocarbonyl Removal

Hansen, Marvin M.,Harkness, Allen R.

, p. 6971 - 6974 (2007/10/02)

A new procedure for synthesis of 4-thiazolidinones from readily available rhodanines is reported.Slow addition of the substrate to excess zinc dust in acetic acid at reflux affords the best yields.Identification of dimeric byproducts led to development of

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