Peptide Synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl Esters of Fluorenylmethoxycarbonyl Amino Acids as Self-indicating Reagents for Solid Phase Peptide Synthesis

DOI: 10.1039/P19880002887

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2887 - 2894 (1988)

Update date:2022-09-26

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Authors:

Atherton, Eric

Holder, Jill L.

Meldal, Morten

Sheppard, Robert C.

Valerio, Robert M.

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Article abstract of DOI:10.1039/P19880002887

The preparation and characterisation of 3,4-dihydro-4-oxo-1,2,3-benzotriazinyl esters (1) of Fmocamino acids and their use in solid phase peptide synthesis is described.Ionisation of the liberated hydroxy component (2) by the starting resin-bound amine pr

Full text of DOI:10.1039/P19880002887

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