Microbial models of mammalian metabolism: Production of 3'-hydroxywarfarin, a new metabolite of warfarin using Cunninghamella elegans

Article abstract of DOI:10.1002/jps.2600800402

Warfarin, an anticoagulant and ''metabolic probe'' for cytochrome P-450 isozyme multiplicity, was metabolized by the fungus Cunninghamella elegans (ATCC 36112) to yield the previously unreported metabolite 3'-hydroxywarfarin. This metabolite was isolated