A VARIANT OF THE BRUYLANTS REACTION. SYNTHESIS OF 4-HETEROARYL-4-ANILINOPIPERIDINES.

DOI: 10.1016/S0040-4039(00)88451-8

Source and publish data:

Tetrahedron Letters p. 6827 - 6830 (1988)

Update date:2022-08-06

Topics:

Authors:

Kudzma, Linas V.

Spencer, H. Kenneth

Severnak, Sherry A.

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Article abstract of DOI:10.1016/S0040-4039(00)88451-8

Imines can be generated in situ from α-aminonitriles and efficiently trapped by a variety of lithiated heterocycles.This variation of the Bruylants reaction has proven to be a general method for the synthesis of α-heteroaryl secondary amines.

Full text of DOI:10.1016/S0040-4039(00)88451-8

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