A Practical Synthesis of Several Polyhydroxylated Chiral Building Blocks

DOI: 10.1246/cl.1987.2163

Source and publish data:

Chemistry Letters p. 2163 - 2166 (1987)

Update date:2022-08-03

Topics:

Authors:

Kusakabe, Masato

Kato, Hiroshi

Sato, Fumie

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Article abstract of DOI:10.1246/cl.1987.2163

A practical method for the synthesis of several useful polyhydroxylated chiral building blocks has been developed.The key reaction is the kinetic resolution of (E)-1-trimethylsilyl-4-alkoxy-1-buten-3-ol or (E)-1-trimethylsilyl-5-alkoxy-1-penten-3-ol using the Sharpless asymmetric epoxidation reaction.

Full text of DOI:10.1246/cl.1987.2163

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