THE USE OF LABILE BASE PROTECTING GROUPS IN OLIGORIBONUCLEOTIDE SYNTHESIS

DOI: 10.1016/S0040-4039(01)80326-9

Source and publish data:

Tetrahedron Letters p. 71 - 74 (1989)

Update date:2022-07-30

Topics: Synthesis Experimental terms Chemical terms Oligoribonucleotide

Authors:

Chaix, Carole

Molko, Didier

Teoule, Robert

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Article abstract of DOI:10.1016/S0040-4039(01)80326-9

The use of phenoxyacetyl group for the protection of the exocyclic amino function of purine bases and acetyl group for cytosine in oligonucleotide synthesis by the cyanoethylphosphoramidite approach is described.A side reaction - i.e. partial replacement of phenoxyacetyl group of protected guanines by acetyl group - was observed during the capping step.It can be avoided by the use of phenoxyacetic anhydride in place of acetic anhydride.

Full text of DOI:10.1016/S0040-4039(01)80326-9

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