Concise Stereoselective Synthesis of (2S,4R)-4-Hydroxyproline from (S)-O-Benzylglycidol by a Novel Cyclization

DOI: 10.1039/c39880001527

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1527 - 1528 (1988)

Update date:2022-08-04

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Authors:

Takano, Seiichi

Iwabuchi, Yoshiharu

Ogasawara, Kunio

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Article abstract of DOI:10.1039/c39880001527

An efficient stereoselective route to (2S,4R)-4-hydroxyproline from (S)-O-benzylglycidol has been established via a novel iodine-mediated cyclization of the N-benzoyl-γ,δ-unsaturated amide.

Full text of DOI:10.1039/c39880001527

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