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593-51-1

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Basic Information
CAS No.: 593-51-1
Name: Methylamine hydrochloride
Molecular Structure:
Molecular Structure of 593-51-1 (Methylamine hydrochloride)
Formula: CH6ClN
Molecular Weight: 67.52
Synonyms: Methanamine,hydrochloride (9CI);Methanaminium chloride;Methylamine monohydrochloride;Methylammonium chloride;
EINECS: 209-795-0
Density: 0.8306 (rough estimate)
Melting Point: 231-233 °C(lit.)
Boiling Point: 38.2 °C at 760 mmHg
Flash Point: 225-230°C/15mm
Solubility: soluble in water
Appearance: white to light tan solid
Hazard Symbols: HarmfulXn
Risk Codes: 22-36/37/38
Safety: 26-37/39
Transport Information:
PSA: 26.02000
LogP: 1.07720
Synthetic route
920-68-3

heptamethyldisilazane

A

107-46-0

Hexamethyldisiloxane

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchlorideA n/a
B 99%
39885-14-8

N-Nitroso-N-methylmethoxymethylamine

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Heating;97%
115584-91-3

(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester

109-89-7

diethylamine

A

593-51-1

methylamine hydrochloride

B

(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions
ConditionsYield
In diethyl ether at -40℃; for 1h;A n/a
B 96%
650-52-2

bis(trifluoromethyl)chlorophosphine

A

431-98-1

methylamino-bis-trifluoromethyl-phosphine

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With CH3NH2 In gaseous matrix 0°C;A 95%
B n/a
18197-25-6

N-formyl-N-methylformamide

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 168h; Ambient temperature;94%
593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
Stage #1: formamide With bis(tetrahydrofuran)calcium di(bis(trimethylsilyl)amide); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere; Schlenk technique;
Stage #2: With hydrogenchloride In diethyl ether; toluene Inert atmosphere; Schlenk technique;
90%
Stage #1: formamide With [(aNHC)KN(SiMe3)2]2; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 40℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;
Stage #2: With water; sodium hydroxide In diethyl ether; toluene at 40℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;
Stage #3: With hydrogenchloride In diethyl ether; water Inert atmosphere; Glovebox; Schlenk technique;
98 %Spectr.
56-40-6

glycine

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
Stage #1: glycine With (R)-Carvone In propan-1-ol at 20 - 190℃; under 11251.1 Torr; for 0.216667h; Sealed tube; Microwave irradiation;
Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h; Microwave irradiation;
86%

C11H17N

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 190℃; for 0.216667h; Temperature; Microwave irradiation; Green chemistry;86%

dichloro(nitrosyl)[tris(3,5-dimethylpyrazolyl)-borato]molybdenum

74-89-5

methylamine

A

Mo(HB(Me2pyz)3)(NO)Cl(NHMe)

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
In ethanol; dichloromethane under N2 soln. Mo(HB(Me2pyz)3)(NO)Cl2 in dichloromethane treated with methylamine (33% ethanolic soln.) and mixt. stirred at room temp. for 30 min; volume solvent reduced in vacuo, Et2O added, (NH3Me)Cl filtered off, filtrate reduced in vacuo; elem. anal.;A 83%
B n/a
75-52-5

nitromethane

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
Stage #1: nitromethane With hydrazine hydrate; zinc In methanol at 20℃; for 0.0666667h;
Stage #2: With hydrogenchloride
80%
With hydrogenchloride; zinc; hydrazinium monoformate In water for 0.0416667h;75%
Stage #1: nitromethane With formic acid; nickel In methanol at 20℃; for 0.0833333h; Reduction;
Stage #2: With hydrogenchloride Addition;
45%
109-89-7

diethylamine

115525-64-9

(E)-2-Chloro-4,4-difluoro-3-hydroxy-but-2-enoic acid methyl ester

A

593-51-1

methylamine hydrochloride

B

115584-97-9

(E)-2-Chloro-4,4-difluoro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions
ConditionsYield
In diethyl ether at -40℃; for 1h;A n/a
B 76%
74-89-5

methylamine

934-16-7

phenylhydroxamoyl chloride

A

28267-98-3

(Z)-N-Methylbenzamid-oxim

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
In diethyl ether for 48h; Ambient temperature;A 76%
B n/a
74-89-5

methylamine

5032-91-7

pentafluorophenyl dichlorophosphine

A

7542-56-5

C6F5P{N(H)CH3}2

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
In diethyl ether byproducts: HCl; in presence of a trap for HCl;A 75%
B n/a
In diethyl ether byproducts: HCl; in presence of a trap for HCl;A 75%
B n/a
109-89-7

diethylamine

115525-65-0

(E)-2-Chloro-4,4,4-trifluoro-3-hydroxy-but-2-enoic acid methyl ester

A

593-51-1

methylamine hydrochloride

B

115584-98-0

(E)-2-Chloro-4,4,4-trifluoro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions
ConditionsYield
In diethyl ether at -40℃; for 1h;A n/a
B 70%
109-89-7

diethylamine

115525-66-1

(E)-2-Chloro-4,4,5,5,6,6,7,7,7-nonafluoro-3-hydroxy-hept-2-enoic acid methyl ester

A

593-51-1

methylamine hydrochloride

B

115584-99-1

(E)-2-Chloro-4,4,5,5,6,6,7,7,7-nonafluoro-3-hydroxy-hept-2-enoic acid methyl ester; compound with diethyl-amine

Conditions
ConditionsYield
In diethyl ether at -40℃; for 1h;A n/a
B 69%
78614-25-2

3-Methylcarbamoylsulfanyl-propionic acid methyl ester

A

870-21-3

3-methylcarbamoylsulfanyl-propionic acid

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride Heating;A 58%
B 15%
71179-85-6

(CO)5MoP(NHCH3)3

A

81432-35-1

pentacarbonyl-[chloro-di(methylamino)phosphane]molybdenum(0)

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In toluene (N2), HCl introduced into a soln. of the Mo-complex at room temp. for 30 min; removed in vacuo, extd. with hexane, filtered, crystd. at -35°C,elem. anal.;A 51.2%
B >99

chromium dichloride

A

chromium (III) ion

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogen cyanide; ammonium chloride In not given in basic soln.; NH4Cl is produced by partial hydrolysis of HCN;A n/a
B 44%
With HCN; NH4Cl In not given in basic soln.; NH4Cl is produced by partial hydrolysis of HCN;A n/a
B 44%
75-54-7

Dichloromethylsilane

74-89-5

methylamine

A

593-51-1

methylamine hydrochloride

B

103873-03-6

1,3-dichloro 1,2,3-trimethyl disilazane

Conditions
ConditionsYield
In tetrahydrofuran at -30℃; for 15h;A n/a
B 43%
75-54-7

Dichloromethylsilane

74-89-5

methylamine

A

593-51-1

methylamine hydrochloride

B

103873-03-6

1,3-dichloro 1,2,3-trimethyl disilazane

C

(1R,5S) and (1S,5R)-1,5-dichloro-1,2,3,4,5-pentamethyltrisilazane

Conditions
ConditionsYield
In pentane 1.) -30 deg C, 8 h; 2.) RT, 12 h;A n/a
B 39%
C 15%
67-56-1

methanol

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; copper-salt; ammonium chloride at 370℃; unter Druck;
With hydrogenchloride; iron-salt; ammonium chloride at 370℃; unter Druck;
With copper-salt; ammonium chloride at 370℃; unter Druck;
With iron-salt; ammonium chloride at 370℃; unter Druck;
50-00-0

formaldehyd

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With water; ammonium chloride
With ammonium chloride at 120 - 210℃;
593-81-7

trimethylamine hydrochloride

A

74-87-3

methylene chloride

B

593-51-1

methylamine hydrochloride

C

75-50-3

trimethylamine

Conditions
ConditionsYield
at 285℃;
50-98-6

ephedrine hydrochloride

A

593-51-1

methylamine hydrochloride

B

93-55-0

1-phenyl-propan-1-one

Conditions
ConditionsYield
Destillation im CO2-Strom;
67-56-1

methanol

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; copper-salt at 370℃; unter Druck;
With hydrogenchloride; iron-salt at 370℃; unter Druck;
74-87-3

methylene chloride

74-89-5

methylamine

A

593-51-1

methylamine hydrochloride

B

75-57-0

tetramethlyammonium chloride

71-23-8

propan-1-ol

703-86-6

2,4,6-trichloro-1,3,5-trimethylborazine

71-43-2

benzene

A

688-71-1

tri-n-propyl borate

B

593-51-1

methylamine hydrochloride

50-00-0

formaldehyd

A

64-18-6

formic acid

B

3088-27-5

monomethanolamine

C

593-51-1

methylamine hydrochloride

D

3684-39-7

N-methylhydroxylamine hydrochloride

Conditions
ConditionsYield
With ammonium chloride; water at 25℃; for 24h; Further byproducts given;
50-00-0

formaldehyd

A

3400-38-2

methylaminomethanol

B

3088-27-5

monomethanolamine

C

593-51-1

methylamine hydrochloride

D

22031-26-1

N-methyldiethanolamine

E

CH5NO*H(1+)

F

3684-39-7

N-methylhydroxylamine hydrochloride

Conditions
ConditionsYield
With ammonium chloride In water at 25℃; for 24h; Mechanism;
124-13-0

Octanal

593-51-1

methylamine hydrochloride

151-50-8

potassium cyanide

112101-12-9

2-Methylamino-nonanenitrile

Conditions
ConditionsYield
With aluminum oxide In acetonitrile at 50℃; for 22h; ultrasound;100%
2011-06-5

2-benzyloxy-3-methoxybenzaldehyde

593-51-1

methylamine hydrochloride

88741-41-7

1-(2-(benzyloxy)-3-methoxyphenyl)-N-methylmethanamine

Conditions
ConditionsYield
With sodium tetrahydroborate100%
593-51-1

methylamine hydrochloride

149967-29-3

N-[(R)-1-[(1,1-dimethylethoxy)carbonyl]-3-(1,3-dihydro-1,3-dioxo-2H-benz[f]isoindol-2-yl)propyl]-L-leucine

154296-26-1

N-<1-(R)-<(1,1-dimethylethoxy)carbonyl>-3-(1,3-dihydro-1,3-dioxo-2H-benzisoindol-2-yl)propyl>-N'-methyl-L-leucinamide

Conditions
ConditionsYield
With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide In dichloromethane for 18h; Ambient temperature;100%
593-51-1

methylamine hydrochloride

2004-06-0

6-Chloropurine riboside

1867-73-8

N6-methyladenosine

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide for 72h;100%
593-51-1

methylamine hydrochloride

151-50-8

potassium cyanide

98-86-2

acetophenone

112101-15-2

2-methylamino-2-phenyl-propionitrile

Conditions
ConditionsYield
With aluminum oxide In acetonitrile at 50℃; for 24h; ultrasound;100%
623950-04-9

4'-carboxyl N-Boc-2',6'-dimethyl-L-phenylalanine methyl ester

593-51-1

methylamine hydrochloride

861676-19-9

methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(2,6-dimethyl-4-(methylcarbamoyl)phenyl)propanoate

Conditions
ConditionsYield
With ammonium chloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; tert-butyl alcohol at 20℃; for 0.666667h;100%
593-51-1

methylamine hydrochloride

126093-01-4

methyl 4-<<<4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylic acid

{1-methyl-5-[1-methyl-5-(1-methyl-5-methylcarbamoyl-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-1H-pyrrol-3-yl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 14h;100%
593-51-1

methylamine hydrochloride

1009303-67-6

5-bromo-2-difluoromethoxy-N-methyl-benzamide

Conditions
ConditionsYield
Stage #1: 5-bromo-2-difluoromethoxy-benzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: methylamine hydrochloride In N,N-dimethyl-formamide at 20℃; for 2h;
100%
621685-61-8

C16H16N4O3

593-51-1

methylamine hydrochloride

621685-62-9

C17H19N5O2

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃;100%
369-34-6

3,4-difluoronitrobenzene

593-51-1

methylamine hydrochloride

124431-92-1

N-methyl-2-fluoro-4-nitroaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 24h;100%
5081-36-7

3-methoxy-4-nitrobenzoic acid

593-51-1

methylamine hydrochloride

878160-13-5

3-methoxy-N-methyl-4-nitrobenzamide

Conditions
ConditionsYield
Stage #1: 3-methoxy-4-nitrobenzoic acid; methylamine hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.0833333h;
Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;
100%
With benzotriazol-1-ol In N,N-dimethyl-formamide at 20℃; for 18h;
593-51-1

methylamine hydrochloride

111-64-8

n-octanoic acid chloride

1119-57-9

N-methyloctanoylamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 5℃; for 2.5h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h;100%
881673-82-1

5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

593-51-1

methylamine hydrochloride

881673-83-2

1-[5-bromo-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol at 20℃; for 1h;100%
With methanol; sodium cyanoborohydride at 20℃; for 1h;100%
With methanol; sodium cyanoborohydride at 10 - 35℃; for 1h;100%
915037-54-6

4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone

593-51-1

methylamine hydrochloride

915037-55-7

N-methyl-4-(5-nitro-1H-indol-3-yl)cyclohex-3-enamine

Conditions
ConditionsYield
Stage #1: 4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone; methylamine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 14h;
Stage #2: With sodium hydroxide In water; 1,2-dichloro-ethane
100%
Stage #1: 4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone; methylamine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 14h;
Stage #2: With sodium hydroxide In water; 1,2-dichloro-ethane
100%
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 14h; Inert atmosphere;54%
15761-38-3

L-N-Boc-Ala

593-51-1

methylamine hydrochloride

84851-00-3

tert-butyl N-[(1S)-1-(methylcarbamoyl)ethyl]carbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 17.5h;100%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In acetonitrile at 25℃; for 10h;68%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;50%
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃; for 12h;
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 2h;
593-51-1

methylamine hydrochloride

126832-81-3

1-(pyridin-4-yl)-4-oxopiperidine

392330-66-4

N-methyl-1-(pyridin-4-yl)piperidin-4-amine

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol at 20℃; for 17h;100%
Stage #1: methylamine hydrochloride; 1-(pyridin-4-yl)-4-oxopiperidine; acetic acid In methanol at 20℃; for 0.333333h;
Stage #2: With sodium cyanoborohydride In methanol at 20℃; for 16h;
593-51-1

methylamine hydrochloride

171348-52-0

2-((tert-butoxycarbonyl)amino)-3-fluoro-3-methylbutanoic acid

171348-53-1

tert-butyl 3-fluoro-3-methyl-1-(methylamino)-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine In dichloromethane for 18h;100%
19099-93-5

benzyl 4-oxo-1-piperidinecarboxylate

593-51-1

methylamine hydrochloride

405057-75-2

4-methylamino-piperidine-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
Stage #1: benzyl 4-oxo-1-piperidinecarboxylate; methylamine hydrochloride With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃;
Stage #2: With sodium hydrogencarbonate In water; 1,2-dichloro-ethane
100%

potassium cyanide

40320-60-3

N-benzhydryl 3-azetidinone

593-51-1

methylamine hydrochloride

1-Benzhydryl-3-methylaminoazetidine-3-carbonitrile

Conditions
ConditionsYield
Stage #1: N-benzhydryl 3-azetidinone; methylamine hydrochloride With acetic acid In methanol at 20℃; for 0.0833333h;
Stage #2: potassium cyanide at 60℃; for 19h;
100%
Stage #1: N-benzhydryl 3-azetidinone; methylamine hydrochloride With acetic acid In methanol at 20℃; for 0.0833333h;
Stage #2: potassium cyanide at 60℃; for 19h;
100%
Stage #1: N-benzhydryl 3-azetidinone; methylamine hydrochloride With acetic acid In methanol at 20℃; for 0.0833333h;
Stage #2: potassium cyanide In methanol at 60℃; for 19h;
100%
876-08-4

p-(chloromethyl)benzoyl chloride

593-51-1

methylamine hydrochloride

220875-88-7

4-(chloromethyl)-N-methylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 1h;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
1177420-61-9

3-Fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzoic acid

593-51-1

methylamine hydrochloride

1177418-90-4

3-fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}-N-methylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;100%
1567687-33-5

2-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid

593-51-1

methylamine hydrochloride

1567688-08-7

(2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2-(methylamino)-2-oxoethyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 48h;100%
1613515-91-5

1-(5-bromopentyl)-5-fluoro-3-iodo-1H-indazole

593-51-1

methylamine hydrochloride

1613516-39-4

5-(5-fluoro-3-iodo-1H-indazol-1-yl)-N-methylpentan-1-amine

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In tetrahydrofuran at 90℃; Sealed tube;100%
593-51-1

methylamine hydrochloride

6404-31-5

Z-D-proline

66877-06-3

benzyl (2R)-2-(methylcarbamoyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 25℃; for 7h;100%

quartz

593-51-1

methylamine hydrochloride

lead(II) chloride

Reaxys ID: 28470677

Reaxys ID: 28470677

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide100%

quartz

593-51-1

methylamine hydrochloride

lead(II) bromide

6876-37-5

methylammonium bromide

lead(II) chloride

Reaxys ID: 28470674

Reaxys ID: 28470674

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide100%

(R)-tert-butyl 3-(5-iodo-2-(methoxycarbonyl)phenoxy)pyrrolidine-1-carboxylate

593-51-1

methylamine hydrochloride

(R)-tert-butyl 3-(5-iodo-2-(methylcarbamoyl)phenoxy)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: (R)-tert-butyl 3-(5-iodo-2-(methoxycarbonyl)phenoxy)pyrrolidine-1-carboxylate With sodium hydroxide In tetrahydrofuran; methanol at 25℃; for 2h;
Stage #2: methylamine hydrochloride With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran; methanol for 2h;
100%
593-51-1

methylamine hydrochloride

530-62-1

1,1'-carbonyldiimidazole

72002-25-6

imidazole-1-carboxylic acid N-methylamide

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 2h;100%
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 2h;75%
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 2h;68%
In N,N-dimethyl-formamide; acetonitrile at 20℃; for 3.25h;57%
In N,N-dimethyl-formamide; acetonitrile at 20℃;9.87 g

C18H17N3O4

593-51-1

methylamine hydrochloride

C19H20N4O3

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;100%

10-bromo-2-carbamoyl-9-fluoro-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-3-carboxylic acid

593-51-1

methylamine hydrochloride

10-bromo-9-fluoro-N3-methyl-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran100%
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Specification

The IUPAC name of this chemical is Methanamine,hydrochloride. With the CAS registry number 593-51-1 and EINECS registry number 209-795-0, it is also named as methanaminium chloride. In addition, the molecular formula is CH6ClN. It is a kind of white to light tan solid and incompatible with strong oxidizing agents. And it may be sensitive with moisture. In addition, it can be used as a reagent for the analysis and used for organic synthesis.

Physical properties about Methylamine hydrochloride are:
(1)ACD/LogP: -0.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.76; (4)ACD/LogD (pH 7.4): -3.54; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)Enthalpy of Vaporization: 25.6 kJ/mol; (12)Boiling Point: 38.2 °C at 760 mmHg; (13)Vapour Pressure: 3970 mmHg at 25°C.

Preparation of Methylamine hydrochloride:
It can be prepared by carboamine solution. Add the hydrochloric acid into the carboamine solution. The pH value should be controlled at 2-3. And then after a series of decoloring, filtration, concentration and crystallization you can get the desired product. The equation is as follows:
Methanamine,hydrochloride (1:1) can be prepared by carboamine solution

Uses of Methylamine hydrochloride:
It can be used to get methylsulfamoyl chloride. This reaction will need reagent SO2Cl2, catalyst SbCl5 and solvent acetonitrile. The yield is about 66%.
Methanamine,hydrochloride (1:1) can be used to get methylsulfamoyl chloride

Safety information of Methylamine hydrochloride:
When you are using Methylamine hydrochloride, please be cautious about it as the following:This chemical is harmful if swallowed. It is irritating to eyes, respiratory system and skin. Whenever you will contact it, please wear gloves and eye/face protection. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: [Cl-].[NH3+]C
(2)InChI: InChI=1/CH5N.ClH/c1-2;/h2H2,1H3;1H
(3)InChIKey: NQMRYBIKMRVZLB-UHFFFAOYAJ

The toxicity data of Methylamine hydrochloride is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin > 2gm/kg (2000mg/kg)   Kodak Company Reports. Vol. 21MAY1971,
mouse LD50 intraperitoneal 2160mg/kg (2160mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
rat LD50 oral 1600mg/kg (1600mg/kg)   Inhalation Toxicology. Vol. 2, Pg. 29, 1990.