ENZYMATIC PREPARATION OF OPTICALLY ACTIVE α AND β-HYDROXYALDEHYDES

Article abstract of DOI:10.1016/0040-4020(89)80119-X

Resolution of protected α and β-hydroxyaldehydes 1a-e, chiral building blocks in the synthesis of natural products, was easily achieved by lipase-catalyzed stereoselective hydrolysis of corresponding acetic or butyric ester derivative.